APS Annual Meeting at Experimental Biology



Sympathetic Transduction: Methods, Sex Differences, and Future Considerations

Symposium — Tuesday, April 5, 2022 — 8:30 AM - 10:00 AM — Convention Center, Room 201B
Neural Control and Autonomic Regulation Section — Chair: Philip Millar — Co-Chair: Lauro C. Vianna

Microneurographic assessment of muscle sympathetic nerve activity (MSNA) provides valuable insight into the neural mechanisms responsible for cardiovascular control at rest and during stress. However, efferent sympathetic outflow can be dissociated from end-organ responsiveness due to differences in neurotransmitter release, adrenergic sensitivity, and non-adrenergic factors. A variety of methods have been developed to quantify the transduction of sympathetic activity (MSNA) into changes in regional vasoconstriction or blood pressure. These methods have been deployed to examine the effects of sex, aging, race, pregnancy, among others on vascular or blood pressure sympathetic transduction. This symposium aims to discuss 1) the common methodologies developed for assessing sympathetic transduction; 2) the effects of sex on sympathetic transduction at rest; 3) the influence of hypoxia on neurovascular transduction; and 4) considerations for interpreting signal-averaged sympathetic transduction data based on the underlying relationship with MSNA burst frequency.

Speakers

  • Introduction
    Philip Millar — Human Health and Nutritional Sciences, University of Guelph

  • Sympathetic Transduction in Human Health and Disease:  Recent Advances and Methodological Considerations
    Paul Fadel — College of Nursing and Health Innovation, University of Texas at Arlington

  • Effects of Sex on Resting Sympathetic Transduction 
    Chloe Taylor — School of Science and Health, Western Sydney University

  • Influence of Hypoxia on Neurovascular Transduction
    Craig D. Steinback — Physical Education and Recreation, University of Alberta

  • Influence of Muscle Sympathetic Burst Frequency on Signal-Averaged Resting Sympathetic Transduction
    Massimo Nardone — Human Health and Nutritional Sciences, University of Guelph

  • Close
    Lauro C. Vianna — NeuroV̇ASQ̇ - Integrative Physiology Laboratory, University of Brasilia




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