APS Annual Meeting at Experimental Biology

Sex Chromosomes and Sex Hormones in Cardiovascular Disease

Featured Topic — Tuesday, April 5, 2022 — 1:30 PM - 3:00 PM — Convention Center, Room 204A
Cardiovascular Section — Chair: Lisa Cassis — Co-Chair: Benard Ogola

The inherent differences in males and females play an important role in cardiovascular disease. Biologic sex is determined by sex chromosomes (XX in female and XY in males) and sex hormones (estrogen/progresterone in females and testosterone in males). The influence of sex chromosomes are manifested at conception and maintained throughout life, while levels of specific sex hormones increase and then decline with aging. The X chromosome accounts for 5% of the human genome and thus can have an immense impact on health and disease. However, genes on the X and the Y chromosome are not typically included in large-scale GWAS studies, thus the influence of genes encoded by the sex chromosomes on cardiovascular disease is poorly understood. There is a need to understand how sex chromosomes and sex hormones contribute to cardiovascular physiology and pathophysiology. This symposium will fill this knowledge gap by highlighting research across an array of fields including epigenetics, immunity, sleep, and vascular biology with the common goal of dissecting the impact of sex hormones versus sex chromosomes on the progression of cardiovascular disease.


  • Genes That Escape X Chromosome Inactivation Influence Sex Differences in Cardiometabolic Health and Drug Treatment
    Karen Reue — Physiology, UCLA

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