APS Annual Meeting at Experimental Biology

Understanding HFpEF pathophysiology in animals for novel therapeutic development

Featured Topic — Sunday, April 3, 2022 — 1:30 PM - 3:00 PM — Convention Center, Room 204C
Cardiovascular Section — Chair: Shyam Nandi

The topic abstracts will cover and include new and novel in vivo modeling approaches for HFpEF research and findings that fulfill to recapitulate pre-clinical assessments resembling human HFpEF. A broad range of in vivo HFpEF research approaches including genetic, non-genetic, dietary combinations, or pharmacological interventions that have fruitfully represented HFpEF features and associated pathophysiology will be discussed and considered in this topic. In addition, novel ideas for small or large animal HFpEF modeling, therapeutic methodologies, surgical interventions having potential clinical values or that mitigate the HFpEF syndrome will be encouraged to participate. Supporting approaches and validations can include large-scale analysis and representation of metabolomics collection, cardiac genomic/proteomic datasets, anatomy, hemodynamics, physiological recordings, and invasive or non-invasive cardiac imaging analyses. This featured topic will be potentially helpful to understand the HFpEF animal pathophysiology and associated mechanism of actions for novel targets and future HFpEF therapeutic developments.


  • The Obese ZSF1 Rat Model of HFpEF for the Assessment of Mechanistic Interrelationship between Coronary Microvascular and Left Ventricle Diastolic Dysfunction
    Zsolt Bagi — Physiology, University of Augusta School of Medicine

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