APS Annual Meeting at Experimental Biology

Mind your Heart in Diabetes: Cardiac and Vascular Consequences of Insulin Resistance

Symposium — Sunday, April 3, 2022 — 8:30 AM - 10:00 AM — Convention Center, Room 204A
Cardiovascular Section — Chair: J. Christopher Baldi — Co-Chair: William Schrage

In the US alone, more than 90 million adults (38%) demonstrate prediabetes (insulin resistance, IR) and another 33 million (10%) suffer from Type 2 Diabetes (T2D). Both conditions markedly increase the risk of cardiac and cerebrovascular diseases that pose tremendous biomedical, financial and personal burdens that will impact over 1.3 billion adults worldwide by 2045. Exactly how systemic IR and diabetes mellitus (DM) accelerates or worsens cardiovascular disease remains largely misunderstood due to variations in severity, longevity, and comorbidities as well as factors unique to IR and DM. New insights into mechanisms that offer the chance to slow or reverse vacular and cardiac dysfunction are essential.


The goal of this symposium is to present new data and ideas relating new physiologic insights regarding pathophysiology in the context of classic clinical markers of IR or T2D.  The target audience is a broad group of physiologists that are reaching across disciplines to understand cardiac, vascular, endocrine, and exercise physiology in a more integrative fashion to solve the complex pathology underlying these conditions.

The symposium will bring together diverse body of experts in both animal models and human disease. Data will span cellular, organ, and whole body function to further our understanding of  how pathophysiology impacts overall cardiovascular health stemming from cardiac and cerebrovascular dysfunction.


The cardiac group starts of with Dr. Darnel Prakoso (Monash University, Australia) who discusses state-of-the-art treatments for diabetic heart failure. The second speaker, Dr. Angela Greenman (University of Otago, NZ), is a young investigator who explores cellular cardiac dysfunction from T2D rat and human tissues.


Next, Dr. Craig Emter (University of Missouri, USA) uses a porcine model to interrogate heart failure in diabetes. Dr. Emter uses this model to investigate cerebrovascular responses  as well, and his talk will serve as a clear segue to the final talk. The human cerebrovascular perspective will be provided by Dr. Katrina Carter (University of Wisconsin, USA), a young investigator who studies mechanisms behind impaired cerebral blood flow in humans with prediabetes under a variety of environmental stressors.


The final 10 minutes will bring all 4 speakers together for aroundtable discussion to conclude the session.


  • Novel Treatments for Diabetic Heart Failure
    Darnel Prakoso — Monash Institute of Pharmaceutical Sciences, Monash University

  • Eight weeks of treadmill running improves calcium sensitivity of force production in diabetic rat cardiomyocytes.
    Angie Greenman — Department of Medicine/HeartOtago, University of Otago

  • Brains, Blood Vessels, and Hearts: Can FSTL1 tie them together in infarcted swine with diabetes?
    Craig A Emter — Biomedical Sciences, University of Missouri - Columbia

  • Cerebrovascular function and dysfunction in prediabetic humans
    Katrina Carter — Dept of Kinesiology, University of Wisconsin-Madison

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