APS Annual Meeting at Experimental Biology

Recent Advances in Ion Transport and Inflammation

Symposium — Monday, April 4, 2022 — 3:30 PM - 5:00 PM — Convention Center, Room 201C
Cell and Molecular Physiology Section — Chair: Eric Delpire — Co-Chair: Liliana Schaefer
AJP-Cell Physiology

The ability of a macrophage to clear apoptotic corpses is modulated by the activity of transporters importing or exporting Cl- ions. The engulfment process (efferocytosis) is accelerated by a decrease in intracellular Cl- while tempered by an increase in Cl-. This process was dissected in great detail in a paper published in Nature Biology in 2019. The author, Justin Perry is a young Assistant Professor at the Sloan Kettering Cancer Institute in New York. Justin will present exciting new data that follow that seminal paper. In the brain, the macrophage function is accomplished by microglia or immune cells of the central nervous system. Their function, including phagocytosis, is also modulated by ion transporters, such as the Na+/H+ exchanger. Dandan Sun is a well-established investigator. She is Professor of Neurology at Pittsburgh University Medical Center. Her expertise focuses on the role of ion transport processes in brain damage following injury or stroke. Our third speaker is Rainelli Koumangoye, a young investigator in Anesthesiology at Vanderbilt University Medical Center. He is the recipient of the 2021 Young Investigator Award from the Cell and Molecular Physiology section. His research focus is on epithelial barrier integrity in the gastrointestinal tract. In recent work published in Cellular and Molecular Gastroenterology & Hepatology he uncovered unanticipated relationships between a basolateral transport mechanism and hydration of the mucus layer in the lumen that protects the intestinal epithelium against bacterial invasion. He has novel data indicating interaction between transporters and tight junction proteins. Overall the symposium is balanced in gender, career levels, and ethnicity. It covers novel aspects of cell physiology related to ion homeostasis and inflammation.


  • Regulation of Chloride Flux during 'Healthy' Apoptotic Cell Clearance
    Justin Perry — Immunology Program, Memorial Sloan Kettering Cancer Center

  • Role of Ion Transport in CNS Inflammation and Stroke
    Dandan Sun — Department of Neurology, Pittsburgh University Medical Center

  • Ion Secretion Protects the Intestinal Epithelia against Pathogen Invasion
    Rainelli Koumangoye — Anesthesiology and Molecular and Biophysics, Vanderbilt University Medical Center

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