APS Annual Meeting at Experimental Biology

SARS-CoV-2: New Mechanistic Insights

Symposium — Tuesday, April 5, 2022 — 3:30 PM - 5:00 PM — Convention Center, Room 204A
Respiration Section — Chair: Karen M Ridge — Co-Chair: Jaime Hook

Respiratory viruses are a major threat to humankind.  This symposium addresses emerging concepts in the basic and translational understanding of viral pneumonia.  Speakers will provide insights into the molecular pathogenesis of severe SARS-CoV-2 pneumonia and attempt to explain some of the bedside observations that garnered attention during the COVID-19 pandemic.  Talks will address the unique host response to SARS-CoV-2, the development of host-targeted therapeutic approaches, and the role of distal lung immune cell populations and fibroblasts in acute and chronic lung injury.  The enormous societal impact of respiratory viruses makes this symposium relevant to the diverse Experimental Biology membership.

The repair and recovery processes from viral pneumonia require the coordinated activation of specific immune and epithelial cell programs to orchestrate the resolution of lung inflammation and repair of lung damage.  We will address these issues in the context of lung injury caused by SARS-CoV-2 infection and highlight recent basic, translational, and clinical research findings that shed new light on virus-induced lung injury and repair mechanisms. 



  • Introduction to the Session
    Jaime Hook — Medicine, Icahn School of Medicine at Mount Sinai

  • A Mouse-Adapted Model of SARS-CoV-2 and Host-Responses to Infection with SARS-CoV-2
    Ralph Baric — Microbiology and Immunology, University of North Carolina at Chapel Hill

  • Age-Determined Expression of Priming Protease TMPRSS2 and Localization of SARS-CoV-2 in the Lung Epithelium
    Jennifer Sucre — Medicine, Vanderbilt University

  • Targeting Fibroblast Responses to Viral Lung Infection
    Paul Thomas — Immunology, St Jude Children’s Research Hospital

  • New Insights Into the Immune Response to SARS-CoV-2 from Human BAL Fluid
    Luisa Morales-Nebreda — Medicine, Northwestern University Feinberg School of Medicine

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