APS Annual Meeting at Experimental Biology

Transition from acute to Chronic Critical Illness After Pneumonia: Long-Term Outcomes, End-Organ Dysfunction and Mechanisms

Featured Topic — Sunday, April 3, 2022 — 8:30 AM - 10:00 AM — Convention Center, Room 203B
Respiration Section — Chair: Brant M Wagener — Co-Chair: Ji Young Lee

Mortality in critically ill patients has decreased due to improvements in hemodynamic support, mechanical ventilation strategies and bundled care. However, patients surviving to discharge have staggering rates of mortality, ~50%, during the next year of life. Furthermore, survivors have significant morbidity due to end-organ dysfunction. An NHBLI report suggests two erroneous paradigms that have limited our understanding of the role of pneumonia on health: that pneumonia is a 1) localized and 2) acute disease. In fact, pneumonia causes end-organ injury by poorly understood mechanisms and the clinical manifestations persist long after resolution of the primary infection. Biological changes occurring during pneumonia that induce long-term morbidity are poorly understood. In summary, we propose to discuss exciting new mechanisms and hypotheses elucidating mechanisms of long-term morbidity and end-organ dysfunction in survivors of pneumonia that suffer from chronic critical illness.


  • Introduction and Clinical Aspects of Chronic Critical Illness After Pneumonia 
    Brant M Wagener — Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham

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