APS Annual Meeting at Experimental Biology

Extracellular Vesicles in GI Physiology and Beyond

Symposium — Monday, April 4, 2022 — 8:30 AM - 10:00 AM — Convention Center, Room 202A
GI and Liver Physiology Section — Chair: Sarah Andres — Co-Chair: Lauren Davey

Extracellular vesicles (EVs) are lipid bilayer-encased particles released from most cells that carry biological cargo to send intercellular signals. These signals can alter the recipient cell’s gene expression, function, or stress response, and promote or ameliroate disease.  EVs are rapidly emerging as important players in gastrointestinal health.  Many types of EVs can impact the digestive system, including those from other tissue types (e.g. adipose tissue, immune cells, or intestinal epithelial cells), the microbiome, or even ingested nutrients. EVs originating from the GI tract or associated microbiota also impact the physiology of distant organs. Although the importance of EVs is repeatedly illustrated, the mechanisms of action, including EV cargo specification, which cargo mediate which signals, how recipient cells are targeted, and how these pathways can be manipulated to improve disease outcomes are all still being described.  This session will include a discussion of how adipose tissue EVs impact colonic stem cells (Arianne Theiss), the interplay between macrophages and intestinal-derived EVs (Wei Ying), and the role of dietary milk EVs in the gut-brain axis (Janos Zempleni). The goal of this symposium will be to provide an integrated perspective on the emerging roles of EVs from different sources in gastrointestinal physiology.


  • The Role of Obese Adipose Tissue Extracellular Vesicles in Altering Colonic Stem Cell Homeostasis
    Arianne Theiss — Department of Medicine, University of Colorado Anschutz Medical Campus

  • CRIg+ Macrophages Prevent Gut Microbial DNA-Containing Extracellular Vesicle Induced
    Tissue Inflammation and Insulin Resistance

    Wei Ying — Medicine, University of California, San Diego

  • Milk Exosomes and the Gut-Brain Axis
    Janos Zempleni — Nutrition and Health Sciences, University of Nebraska-Lincoln

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