APS Annual Meeting at Experimental Biology

Skeletal Muscle Microvascular Fnction and Metabolism: Novel Approaches, Clinical Applications, and Innovative Therapies

Featured Topic — Tuesday, April 5, 2022 — 1:30 PM - 3:00 PM — Convention Center, Room 201A
Environmental and Exercise Physiology Section — Chair: David A Reiter

Maintenance and function of skeletal muscle is reliant on aerobic metabolism which comprises the vast majority of energy production both at rest and during activity. The ability of muscle to meet the wide range of metabolic demands during daily living is dependent on both microvascular supply and function. A variety of new experimental approaches have greatly improved access to more specific microvascular properties leading to more contemporary views on capillary properties, flux of plasma and red blood cells, skeletal muscle oxygen extraction, and coupling of microcirculation with muscle energy production and muscle function. Novel non-invasive approaches have provided greater access to microcirculatory properties allowing for their translation to improved understanding of pathogenesis and efficacy of therapeutic interventions in humans. This has also has set the stage novel therapeutic strategies that are able to more specifically target pathology. The objective of this featured topic is to showcase emerging work in skeletal muscle microcirculation and metabolism. Featured presenter Dr. Michael Nelson will provide an overview of translational work using non-invasive optical methods with his talk on “Skeletal muscle microvascular oxygen delivery and utilization: trials and tribulations of near-infrared spectroscopy and diffuse correlation spectroscopy”. The remainder of this session will be comprised of presentations that highlight innovative approaches, clinical applications, and novel therapies.


  • Skeletal Muscle Microvascular Oxygen Delivery and Utilization: Trials and Tribulations of Near-infrared Diffuse Correlation Spectroscopy
    Michael Nelson — Kinesiology, University of Texas Arlington

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