APS Annual Meeting at Experimental Biology

Sex Differences in Lung Pathophysiology

Symposium — Sunday, April 3, 2022 — 1:30 PM - 3:00 PM — Convention Center, Room 202A
Respiration Section — Chair: Patricia Silveyra — Co-Chair: Alicia Rizzo

Sex differences in the susceptibility, pathophysiology, and outcomes of a wide variety of lung diseases have been reported. Although the mechanisms underlying these differences are incompletely understood, exciting recent work by multiple research groups has identified genetic, hormonal, and environmental factors that are contributing to these disparities. This session will highlight this recent work, which employs in vitro, animal, and clinical models, to understand the roles of sex hormones, gene expression regulation, epigenetics, and immunology in the observed sex differences in bronchopulmonary dysplasia, pulmonary hypertension, asthma, and acute lung injury. Thus, this proposal aims to highlight and encourage discussion of both (1) the pathophysiologic factors driving sex differences in lung disease across the lifespan and (2) the importance of including sex as a biological variable in experimental studies. Additionally, both the scientific content and the presenter/discussant profile demonstrate a critical focus on diversity, inclusion, and health disparities (2/2 chairpersons and 3/4 speakers are women, and our proposal incorporates participation from scientists in career stages ranging from post-doctoral research fellows through senior faculty). 


  • Mechanisms of Estrogen Regulation in Pulmonary Arterial Hypertension
    Andrea Frump — Medicine, Indiana University School of Medicine

  • Sex Differences and Airway Epithelial Differentiation in Asthma
    Sergio Chiarella — Medicine, Mayo Clinic

  • Sex Differences in Respiratory Responses to Inhaled Pollutants
    Meghan Rebuli — Pediatrics, University of North Carolina at Chapel Hill

  • Mechanisms Driving Sex Differences in Neonatal Lung Disease
    Krithika Lingappan — Pediatrics, Children's Hospital of Philadelphia

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