APS Annual Meeting at Experimental Biology

Liver Diseases and Organ Crosstalk: Microbiome, Metabolites and Mechanisms

Symposium — Sunday, April 3, 2022 — 8:30 AM - 10:00 AM — Convention Center, Room 201C
GI and Liver Physiology Section — Chair: Jun Sun — Co-Chair: Melanie Gareau

Only recently have we begun to appreciate the role of microbiome and microbial metabolites in health and disease. Environmental factors and change of lifestyle, including diet, significantly shape the human microbiome, which in turn appears to modify gut barrier function, affect the absorption of nutrients and  electrolytes and induce inflammation. Microbial metabolites may impact a number of host functions and are thus implicated in a variety of pathophysiological conditions, including intestinal disorders, obesity, and liver disease. Approaches that can reshape the liver-gut axis and crosstalk between other organs  represent a reasonable strategy for the development of novel therapeutic approaches. The goals of this symposium are to introduce the researchers and trainees to the recent progress and intersection between the microbiome and metabolism on pathophysiology of liver diseases. This session will include discussions on the contribution of the microbiome to gut barrier function and liver disease (Fengyuan Li) and hepatic bile acid metabolism (David Wang), as well as intestine-liver crosstalk in liver metabolism (Bo Kong). Together, this symposium will provide an integrated perspective on the role of the microbiome and metabolism for  physiologists and trainees working on digestive and metabolic diseases.


  • Introduction
    Jun Sun — Medicine, University of Illinois at Chicago
    8:30 AM - 8:35 AM

  • Probiotics, Bacterial Intestinal AhR Activation and Gut Barrier Function in Liver Disease
    Fengyuan Li — Department of Pharmacology and Toxicology, University of Louisville
    8:35 AM - 9:00 AM

  • Intestine-Liver Crosstalk in Liver Metabolism 
    Bo Kong — Department of Pharmacology and Toxicology, Rutgers University
    9:00 AM - 9:25 AM

  • Role of Intestinal Microbiome in Hepatic Bile Acid Metabolism and Cholesterol Gallstone Formation
    David Wang — Departments of Medicine and Genetics, Albert Einstein College of Medicine
    9:25 AM - 9:50 AM

  • Close
    Melanie Gareau — Anatomy, Physiology & Cell Biology, University of California Davis
    9:50 AM - 10:00 AM

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