APS Annual Meeting at Experimental Biology

Insightful Multi-Omics Approaches: From Clinical Contexts to Extreme Environments

Symposium — Friday, April 30, 2021 — 10:00 AM - 11:30 AM — Virtual Session, Room APS-3
Physiological Omics Group — Chair: Christian Delles — Co-Chair: James Yu

Pathway responses to environmental and pathological challenges provide important clues to the adaptive and maladaptive mechanisms underlying health and disease. It has often been proposed that multidimensional and high-resolution omics data will provide deep insight into physiology and pathophysiology. However, in practice it is not straightforward to bring information from different omics experiments together and to integrate this information with data from traditional physiology e.g., on organ function. This symposium will focus on various uses of state-of-the-art –omic technologies in studies of unique clinical and environmental contexts, including evolutionary adaptations revealed through transcriptomes, developmentally and clinically relevant changes in the epigenome, and –omic differences that might become more commonplace with future environmental endeavors such as space travel. Each presentation brings insight from a different model, environmental context, and approach to provide a highly integrative physiological –omics perspective.


  • Introduction
    Dr. Christian Delles and James Yu —
    10:00 AM - 10:05 AM

  • Integrating Genomic and Physiologic Data to Uncover Mechanisms Regulating Fetal Growth at High Altitude
    Colleen Julian — Division of Biomedical Informatics & Personalized Medicine, University of Colorado Denver - Anschutz Medical Campus
    10:05 AM - 10:25 AM

  • Combined Transcriptomics and Methylomics to Define Etiologies of Human Heart Failure
    Adam Wende — Pathology, University of Alabama at Birmingham
    10:25 AM - 10:45 AM

  • Linking the Development of Diving Ability to Regulatory RNA Expression in the Weddell Seal
    Allyson Hindle — University of Nevada, Las Vegas
    10:45 AM - 11:05 AM

  • Insights from Twin Studies: Omic Effects of Pursuing the Final Frontier
    Brinda Rana — Psychiatry, University of California San Diego
    11:05 AM - 11:25 AM

  • Conclusion
    Dr. Christian Delles and James Yu —
    11:25 AM - 11:30 AM

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