Hallmarks of Aging in the Heart
Symposium — Thursday, April 29, 2021 — 10:00 AM - 11:30 AM — Virtual Session, Room APS-1
National Institutes on Aging — Chair: Candace Kerr — Co-Chair: John Williams
Cardiac aging is associated with increased prevalence of left ventricular hypertrophy, a decline in diastolic function, preserved systolic function at rest with declines in exercise capacity, and an increased prevalence of atrial fibrillation. Recent findings show diverse mechanisms that support a role for several aging hallmarks including inflammation, oxidative stress and metabolic dysfunction that contribute to cardiac aging. This Featured Topic session will discuss cutting edge research on the cellular mechanisms of aging which contribute to the pathological features of cardiac aging and heart failure.
Speakers
- Introduction
Candace Kerr — National Institutes of Health
10:00 AM
- 10:05 AM
- Geroscience Approach to Heart Failure Therapeutic Discovery
Jason Roh — Cardiac Unit Associates-Senior Health Clinic, Massachusetts General Hospital
10:05 AM
- 10:25 AM
- BAT as a Therapeutic for Cardiac Dysfunction with Senescence
Kristin Stanford — Physiology and Cell Biology, Ohio State University College of Medicine
10:25 AM
- 10:45 AM
- Addressing Controversies in the Role of GDF11 in Cardiac Aging
Richard T. Lee — Stem Cell and Regenerative Biology, Harvard University Stem Cell Institute
10:45 AM
- 11:05 AM
- Targeting Hallmarks of Aging: Interventions to Reverse Age-Related Cardiac Dysfunction
Ann Chiao — Aging and Metabolism Research, Oklahoma Medical Research Foundation
11:05 AM
- 11:25 AM
- Conclusion
Candace Kerr — National Institutes of Health
11:25 AM
- 11:30 AM