APS Annual Meeting at Experimental Biology

Hallmarks of Aging in the Heart

Symposium — Thursday, April 29, 2021 — 10:00 AM - 11:30 AM — Virtual Session, Room APS-1
National Institutes on Aging — Chair: Candace Kerr — Co-Chair: John Williams

Cardiac aging is associated with increased prevalence of left ventricular hypertrophy, a decline in diastolic function, preserved systolic function at rest with declines in exercise capacity, and an increased prevalence of atrial fibrillation.  Recent findings show diverse mechanisms that support a role for several aging hallmarks including inflammation, oxidative stress and metabolic dysfunction that contribute to cardiac aging. This Featured Topic session will discuss cutting edge research on the cellular mechanisms of aging which contribute to the pathological features of cardiac aging and heart failure.


  • Introduction
    Candace Kerr — National Institutes of Health
    10:00 AM - 10:05 AM

  • Geroscience Approach to Heart Failure Therapeutic Discovery
    Jason Roh — Cardiac Unit Associates-Senior Health Clinic, Massachusetts General Hospital
    10:05 AM - 10:25 AM

  • BAT as a Therapeutic for Cardiac Dysfunction with Senescence
    Kristin Stanford — Physiology and Cell Biology, Ohio State University College of Medicine
    10:25 AM - 10:45 AM

  • Addressing Controversies in the Role of GDF11 in Cardiac Aging
    Richard T. Lee — Stem Cell and Regenerative Biology, Harvard University Stem Cell Institute
    10:45 AM - 11:05 AM

  • Targeting Hallmarks of Aging: Interventions to Reverse Age-Related Cardiac Dysfunction
    Ann Chiao — Aging and Metabolism Research, Oklahoma Medical Research Foundation
    11:05 AM - 11:25 AM

  • Conclusion
    Candace Kerr — National Institutes of Health
    11:25 AM - 11:30 AM

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