APS Annual Meeting at Experimental Biology

Sex Differences in COVID-19

Symposium — Thursday, April 29, 2021 — 10:00 AM - 11:30 AM — , Room APS-4
Sex/Gender Research Interest Group — Chair: Nina Stachenfeld — Co-Chair:

Worldwide and United States data indicate greater severity of illness and mortality in men with the SARS/CoV-2 infection, a pattern opposite to influenza outbreaks in which sickness and death are often higher in women.   Our first speaker, Akiko Iwasaki, will describe sex differences in the complex interaction of immune cells and antibodies throughout the course of the disease and how this influences health outcomes.  Catherine Gebhard will focus on how estrogens and estrogen receptors regulate the expression of the ACE2 receptor in SARS-CoV-2.  Our final speaker, Gloria Huang will provide a clinical perspective. She will address how estrogen replacement therapy,  taking SERMS or androgen inhibitors impact disease progression in COVID-19 infected women. Together these talks will address key findings regarding sex differences in the progression of the SARS/CoV-2 infection and COVID-19.  A better understanding of sex differences in the immune response to the SARS/CoV-2 infection and to the COVID-19 illness are likely to provide key insights into effective treatments and vaccines.


  • Introduction
    Nina Stachenfeld — OB/Gyn and Reproductive Sciences, John B. Pierce Laboratory, Yale School of Medicine
    10:00 AM - 10:10 AM

  • Sex Differences in Immune Responses to SARS-CoV-2, the Virus which Causes COVID-19.
    Akiko Iwasaki — Immunobiology, Yale School of Medicine
    10:10 AM - 10:35 AM

  • Sex Differences in ACE2 Receptor Expression in COVID.
    Catherine Gebhard — Nuclear Medicine, University Hospital Zurich
    10:35 AM - 11:00 AM

  • Older COVID-19 Infected Women Taking ERT, SERMS or AI’s.
    Gloria Huang — OB/Gyn and Reproductive Sciences, Yale School of Medicine
    11:00 AM - 11:25 AM

  • Conclusion
    Nina Stachenfeld — OB/Gyn and Reproductive Sciences, John B. Pierce Laboratory Yale School of Medicine
    11:25 AM - 11:30 AM

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