APS Annual Meeting at Experimental Biology

Signaling Mechanisms Underlying Vascular Complications in Type 2 Diabetes Mellitus

Symposium — Thursday, April 29, 2021 — 4:00 PM - 5:30 PM — Virtual Session, Room APS-6
Cardiovascular Section — Chair: William Hughes — Co-Chair: Liya Yin

Type 2 diabetes mellitus (T2DM) is an independent risk factor for cardiovascular disease by induction of endothelial dysfunction. Conduit arteries supply bulk blood flow to tissues, while the microvasculature perfuses tissue, allowing for adequate oxygen delivery. T2DM impacts both the macro-and microvasculature, resulting in endothelial dysfunction to varying degrees. The signaling mechanisms by which this dysfunction occurs are abundant, and the expertise of the speakers spans both pre-clinical and clinical models, providing further insight into the vascular pathophysiology of T2DM.


  • Introduction
    William Hughes — Cardiovascular Center, Medical College of Wisconsin
    4:00 PM - 4:05 PM

  • Intersection of Endothelial Mitochondrial Physiology and Type 2 Diabetes Mellitus
    Jessica Fetterman — Medicine, Boston University
    4:05 PM - 4:30 PM

  • Endothelial Insulin Resistance and Vascular Dysfunction as a Consequence of Type 2 Diabetes Mellitus
    Jaume Padilla — Nutrition and Exercise Physiology, University of Missouri-Colombia
    4:30 PM - 4:55 PM

  • Coronary Microvascular Disease in Diabetes: Sex Differences and Mouse Models
    Ayako Makino — Department of Medicine, University of California, San Diego
    4:55 PM - 5:20 PM

  • Conclusion
    Liya Yin — Integrative Medical Sciences, Northeast Ohio Medical University
    5:20 PM - 5:30 PM

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