APS Annual Meeting at Experimental Biology

Circadian Medicine for Cardiovascular Health and Disease

Symposium — Tuesday, April 27, 2021 — 4:00 PM - 5:30 PM — Virtual Session, Room APS-6
Cardiovascular Section — Chair: Tami Martino — Co-Chair: Martin E. Young

The field of circadian rhythms was awarded the 2017 Nobel Prize in Physiology or Medicine, and specifically 3 chronobiologists for discovery of the circadian clock mechanism. Simply put, the circadian clock mechanisms are encoded in our DNA, and are fundamentally important because we are living organisms surviving on a planet with a 24-hour day and night cycle. They help us to adapt to light and dark, activity and rest, wake and sleep. The clocks regulate daily rhythms important for physiology, and especially for healthy cardiovascular physiology. There is daily variation in heart rate, blood pressure, endocrine hormones, and sympathetic and parasympathetic biases of our autonomic nervous system. There are diurnal rhythms in the timing of onset of adverse cardiovascular events - myocardial infarction, arrhythmias, aortic aneurysms, and mortality following percutaneous coronary interventions, angioplasty, or aortic valve replacement. Disturbing rhythms (e.g. shift work, sleep disorders) exacerbates disease; this is especially relevant to the cardiovascular system. Now that the basic physiology is understood, the leading edge is application to clinical medicine.


  • Introduction
    Tami Martino — University of Guelph
    4:00 PM - 4:05 PM

  • Circadian Governance of Cardiac Metabolism
    Martin E. Young — Department of Medicine, University of Alabama at Birmingham, Division of Cardiovascular Diseases
    4:05 PM - 4:20 PM

  • Circadian Control of the Microcirculation
    Steffan-Sebastian Bolz — Physiology, Toronto Centre for Microvascular Medicine, Translational Biology & Engineering, University of Toronto
    4:20 PM - 4:35 PM

  • Renal Disease and the Circadian Clock Mechanism
    Michelle Gumz — Department of Medicine, Division of Nephrology, Hypertension and Renal Transplantation, University of Florida
    4:35 PM - 4:50 PM

  • Circadian Regulation of Autophagy in Cardiac Repair
    Lorrie Kirshenbaum — St Boniface Hospital Albrechtsen Research Centre, The Institute of Cardiovascular Sciences
    4:50 PM - 5:05 PM

  • Circadian Medicine: A Pill to Cure Heart Attacks
    Tami A. Martino — Department of Biomedical Sciences, University of Guelph, Centre for Cardiovascular Investigations
    5:05 PM - 5:20 PM

  • Conclusion
    Tami Martino — University of Guelph
    5:20 PM - 5:30 PM

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