APS Annual Meeting at Experimental Biology

Large Artery Stiffness and the Brain

Symposium — Wednesday, April 28, 2021 — 4:00 PM - 5:30 PM — Virtual Session, Room APS-6
Cardiovascular Section — Chair: Ashley Walker — Co-Chair: Lyndsey DuBose

Two of the greatest risk factors for dementia and late-onset Alzheimer’s disease are old age and cardiovascular diseases. A key feature of the aging cardiovascular system is an increase in stiffness of the large elastic arteries. Numerous recent epidemiological studies have identified correlations between greater large artery stiffness and cognitive impairment and/or Alzheimer’s disease. Despite ample correlative evidence for these associations, an understanding of the underlying mechanisms is lacking. This symposium brings together investigators at the forefront of research to identify the mechanisms by which increased large artery stiffness leads to impairment in the brain. The expert panel will explore the effects of large artery stiffness on cognitive impairment, neuroinflammation, neuropathology, and cerebrovascular dysfunction from both clinical and basic science approaches. By better understanding the mechanisms that underlie the association of large artery stiffness and negative outcomes in the brain, the hope is to identify novel therapeutic targets for the prevention or treatment of dementia and late-onset Alzheimer’s disease.


  • Introduction
    Ashley Walker — Human Physiology, University of Oregon
    4:00 PM - 4:05 PM

  • Arterial Stiffness, Cerebrovascular Dysfunction and Memory
    Gary Mitchell — Cardiovascular Engineering, Inc.
    4:05 PM - 4:25 PM

  • Carotid Calcification and Brain Health: Sex Specific Vulnerability?
    Hélène Girouard — Département de Pharmacologie et Physiologie, Université de Montréal
    4:25 PM - 4:45 PM

  • Targeting Cytoskeletal Protein-Protein Interfaces to Decrease Aortic Stiffness, Brain Bleeds and Dementia
    Kathleen Morgan — Dept. of Health Sciences, Boston University
    4:45 PM - 5:05 PM

  • Interaction of Large Artery Stiffness and Amyloid-Beta on Cerebrovascular Function
    Ashley Walker — Department of Human Physiology, University of Oregon
    5:05 PM - 5:25 PM

  • Conclusion
    Lyndsey DuBose — Medicine, University of Colorado Anschutz Medical Campus
    5:25 PM - 5:30 PM

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