APS Annual Meeting at Experimental Biology

Fundamental Mechanisms of Cellular Aging in Cardiovascular Disease

Featured Topic — Tuesday, April 27, 2021 — 4:00 PM - 5:30 PM — Virtual Session, Room APS-7
Cardiovascular Section — Chair: Eric Thorin — Co-Chair: Martin R. Bennett

In the past decade, important studies have incriminated cellular senescence to promote chronic diseases in old age, including cardiovascular diseases (CVD). Senescent cells no longer divide and are resistant to apoptosis, leading with time to their accumulation. The senescence-associated secretory phenotype of these cells is inflammatory and likely contributes to the low grade, systemic, cold inflammation that nourishes chronic age-related diseases. Using genetic engineering for on-demand ablation of p16 positive cells, a cell division lock upregulated in senescent cells, a causal association has been demonstrated between CVD and senescent cells in mice. A new of drugs, named senolytics, aim at targeting senescent cells to induce their apoptosis and thus, their elimination that should reduce the background inflammation and slow disease progression. It is however, a new field of research, and understanding the pathways of senescence will determine whether or not senolytics will be successful at reducing the burden of age-related CVD.


  • Introductions
    Eric Thorin — Surgery, Université de Montréal
    4:00 PM - 4:02 PM

  • Cellular and Extracellular Mechanisms of Vascular Aging
    Martin R. Bennett — Division of Cardiovascular Medicine, University of Cambridge
    4:02 PM - 4:25 PM

  • Discussion

    Eric Thorin — Surgery, Université de Montréal
    4:25 PM - 4:30 PM

  • Abstract 1 - Mechanisms for the Age-Related Differences in Cerebral Artery Endothelial Function After Exposure to Elevated Pulse Pressure
    Nick R. Winder — Human Physiology, University of Oregon
    4:30 PM - 4:45 PM

  • Abstract 2 - Aged Elastin Haploinsufficient Mice Have Impairments in Memory, Motor Coordination, and Cerebral Artery Endothelial Function
    Sahana Krshna Kumaran — Human Physiology, University of Oregon
    4:45 PM - 5:00 PM

  • Abstract 3 - Mechanisms Underlying the Altered Bioenergetics of Aged Brain Microvasculature
    Siva S.V.P. Sakamuri — Pharmacology, Tulane University School of Medicine
    5:00 PM - 5:15 PM

  • Abstract 4 - Transcriptomic Analysis Of Cardiac Gene Expression Across The Life-Course In Male And Female Mice
    Aykhan Yusifov — Kinesiology and Health, University of Wyoming
    5:15 PM - 5:30 PM

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