APS Annual Meeting at Experimental Biology

Novel Therapeutic Approaches to Cardiovascular and Metabolic Disease

Featured Topic — Wednesday, April 28, 2021 — 2:00 PM - 3:30 PM — Virtual Session, Room APS-6
Cardiovascular Section — Chair: Ryan A. Harris — Co-Chair: Camila Manrique

Cardiovascular disease (CVD) remains the leading cause of death in the US. Many co-morbid conditions to CVD exist, including metabolic disorders such as diabetes, obesity, and lipidemia. Most importantly, the presence of metabolic disorders accelerates the risk for developing CVD and there are emerging data that demonstrate sex plays an important role.  Potential mechanisms for the increased risk for CVD include elevated inflammation and oxidative stress; however, many other physiological pathways have been implicated. Understanding the link between metabolic disorders and CVD will lead to the development of novel therapeutic approaches that can help reduce the risk and overall prevalence of heart disease. 


  • Introduction
    Ryan A. Harris — Augusta University
    2:00 PM - 2:02 PM

  • Vascular Dysfunction in Cardiometabolic Disease Patients: Novel Approaches
    Michael E. Widlansky — Medicine and Pharmacology, Medical College of Wisconsin
    2:02 PM - 2:25 PM

  • Discussion
    Invited Speaker Discussion —
    2:25 PM - 2:30 PM

  • Abstract 1 - NAD+ Redox Imbalance Exacerbates Diabetic Cardiomyopathy via Enhanced Troponin I Phosphorylation, Impaired Energetics and Prolonged Cardiac Relaxation
    Chi Fung Lee — Oklahoma Medical Research Foundation
    2:30 PM - 2:45 PM

  • Abstract 2 - Apigenin Restores Endothelial Function by Ameliorating Oxidative Stress, Prevents Foam Cell Formation, Reverses Aortic Stiffening, and Mitigates Vascular Inflammation with Aging
    Zachary S. Clayton — Integrative Physiology, University of Colorado Boulder
    2:45 PM - 3:00 PM

  • Abstract 3 - Sodium Glucose Transporter 2 Inhibition Reduces Arterial Stiffness and Improves Endothelial Function in a Mouse Model of Aging
    Rogerio N. Soares — Dalton Cardiovascular Research Center, University of Missouri
    3:00 PM - 3:15 PM

  • Abstract 4 - Time Restricted Feeding Ameliorates Cardiac Dysfunction and Impaired Cardiac Metabolism Induced by Simulated Microgravity
    Xinpei Wang — School of Aerospace, Fourth Military Medical University
    3:15 PM - 3:30 PM

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