APS Annual Meeting at Experimental Biology

Sex Differences in Cerebrovascular Function in Health & Disease

Featured Topic — Wednesday, April 28, 2021 — 10:00 AM - 11:30 AM — Virtual Session, Room APS-7
Cardiovascular Section — Chair: Paulo W. Pires — Co-Chair: Kristen L. Zuloaga

This featured topic will highlight novel findings regarding sex differences in cerebrovascular function in both health and disease, with an emphasis on mechanisms pertaining women’s health. Topics of interest include: 1) regulation of cerebral blood flow between males and females, as well as mechanisms responsible for sex differences; 2) Sex disparities in how chronic neurological and cardiovascular/ metabolic disorders affect the finely-tuned cerebral microcirculation; 3)  Sex differences in how blood brain barrier dysfunction or dysfunction in neurovascular coupling, the mechanism by which blood flow is directed to discrete regions of augmented neuronal activity, contributes to cognitive impairment and dementia; 4) How sex hormones modulate cerebral vascular reactivity, thus impacting blood flow regulation, and potentially affecting neurovascular coupling, and, in the long-term, cognitive health; 5) The effects of menopause on cerebral vascular function and responses to injury.


  • Introductions
    Paulo W. Pires — Physiology, University of Arizona
    10:00 AM - 10:02 AM

  • Sex Differences in Vascular Contributions in Dementia
    Kristen L. Zuloaga — Neuroscience and Experimental Therapeutics, Albany Medical College
    10:02 AM - 10:25 AM

  • Discussion
    Invited Speaker Discussion —
    10:25 AM - 10:30 AM

  • Abstract 1 - Sexual Dimorphisms in Hypertension-Associated Cerebrovascular Damage
    Laura C. Chambers — Pharmacology and Toxicology, Michigan State University
    10:30 AM - 10:45 AM

  • Abstract 2 - Modulation of the Acute Cerebrovascular Response to Ischemic Stroke by Sex Hormones is Dependent on Rho-Kinase
    Joanna Raman-Nair — Research Institute, Ottawa Hospital
    10:45 AM - 11:00 AM

  • Abstract 3 - Sex Differences in the Relation Between Frailty and Endothelial Function in Old Mice
    Mackenzie N. Kehmeier — Human Physiology, University of Oregon
    11:00 AM - 11:15 AM

  • Abstract 4 - Differences in Hypercapnia-Induced Cerebral Vasodilation Between Young, Black Men and Women
    John D. Akins — Kinesiology, University of Texas at Arlington
    11:15 AM - 11:30 AM

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