APS Annual Meeting at Experimental Biology

No Place for Social Distancing: Host-Microbe Interactions in Regulation of the Mucosal Barrier

Symposium — Thursday, April 29, 2021 — 10:00 AM - 11:30 AM — Virtual Session, Room APS-9
GI and Liver Physiology Section — Chair: Declan F. McCole — Co-Chair: Izumi Kaji

It is increasingly evident that the gut microbiota significantly impacts human health with notable effects on gut function, host metabolism, cardiovascular health, behavior, and many other physiological systems. Commensal bacteria promote intestinal mucosal health by fortifying barrier integrity, participating in digestive processes, maturation of the immune system, and inhibiting pro-inflammatory responses and pathogen colonization. In contrast, expansion of bacterial strains with the potential to cause disease (pathobionts) can compromise epithelial tight junction proteins, weaken the intestinal barrier and promote pro-inflammatory signaling.      

To understand the impact of the gut microbiota on intestinal physiology we must consider the major site of interaction: the intestinal barrier. The broader interpretation of the intestinal barrier involves the interplay of multiple components: intestinal epithelial cells, the gut microbiota, and mucosal immune cells. In this symposium, we will summarize the present understanding of how the interaction between these compartments can either maintain healthy homeostasis or promote/induce inflammatory disease.


  • Introduction
    Declan F. McCole — Biomedical Sciences, University of California, Riverside
    10:00 AM - 10:05 AM

  • Intraepithelial Lymphocyte/Epithelial Interactions in Maintenance of the Intestinal Barrier
    Karen Edelblum — Pathology and Laboratory Medicine,, Rutgers New Jersey Medical School
    10:05 AM - 10:30 AM

  • Coordination of Intestinal Barrier Properties by Epithelial-Macrophage Crosstalk
    Marianne Spalinger — Biomedical Sciences, University of California, Riverside
    10:30 AM - 10:55 AM

  • Mechanisms of Host-Microbe and Microbe-Microbe Competition in the Inflamed Gut
    Manuela Raffatellu — Pediatrics, University of California, San Diego
    10:55 AM - 11:20 AM

  • Conclusion
    Declan McCole — Biomedical Sciences, University of California, Riverside
    11:20 AM - 11:30 AM

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