Exosomes in the Central Nervous System: Bursting the Bubble

Featured Topic — Friday, April 30, 2021 — 10:00 AM - 11:30 AM — Virtual Session, Room APS-13
Neural Control and Autonomic Regulation Section — Chair: Eric Lazartigues — Co-Chair: Ji Bihl

This FT will present new evidence about the pathologic and therapeutic roles of exosomes within the central nervous system. In addition, it will address the question about the active role of exosomes: are they a garbage disposal mechanism or are they involved in signaling. Finally, can they be manipulated to deliver therapies to the CNS?This FT will present new evidence about the pathologic and therapeutic roles of exosomes within the central nervous system. In addition, it will address the question about the active role of exosomes: are they a garbage disposal mechanism or are they involved in signaling. Finally, can they be manipulated to deliver therapies to the CNS?

Speakers

• Introductions
  Eric Lazartigues — Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center
  10:00 AM - 10:02 AM


• Introduction to Exosomes and Microvesicles
  Ji Bihl — Biomedical Sciences, Marshall University
  10:02 AM - 10:23 AM


• Targeting Hypothalamic AMPK with Exosomes: A Suitable Strategy for Obesity?
  Miguel Lopez — Physiology, University of Santiago de Compostela
  10:23 AM - 10:50 AM


• Discussion
  Eric Lazartigues — Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center
  10:50 AM - 11:00 AM


• Abstract 1 - Heart-Brain Communication by Extracellular Vesicles Contributes to the Sympatho-Excitation in Chronic Heart Failure by Targeting Nrf2/ARE Signaling
  Changhai Tian — Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center
  11:00 AM - 11:15 AM


• Abstract 2 - ADAM17-Enriched Exosomes Contribute to Neuronal Activation in Hypertension
  Navya Lakkappa — Pharmacology, Louisiana State University Health Sciences Center
  11:15 AM - 11:30 AM