APS Annual Meeting at Experimental Biology

Nuclear Receptors and Metabolism

Featured Topic — Wednesday, April 28, 2021 — 2:00 PM - 3:30 PM — Virtual Session, Room APS-9
Endocrinology and Metabolism Section — Chair: Terry D. Hinds — Co-Chair: David E. Stec

Nuclear receptors (NRs) are transcription factors that, over the past two decades, have emerged as significant components in nutrient sensing. Several NRs are activated by natural ligands, including fatty acids, cholesterol, bilirubin, bile acids, eicosanoids, and others. Activation of some NRs induces fat storage, while others reduce fat accumulation. The balance of the NR signaling is essential for homeostasis, and imbalances in NR signaling may underlie the development of obesity and metabolic dysfunction. This session will discuss NRs and metabolic control and how they affect disorders such as obesity, fatty liver, type II diabetes, and other metabolic complications.


  • Introductions
    Chairs, Dr. Terry Hinds and Dr. David Stec —
    2:00 PM - 2:02 PM

  • Roles of PPARs in Liver Health and Diseases
    Walter Wahli — Center for Integrative Genomics, University of Lausanne
    2:02 PM - 2:25 PM

  • Moderated Discussion
    Invited Speaker Discussion —
    2:25 PM - 2:30 PM

  • Abstract 1 - Bilirubin Nanoparticles Activate PPARalpha to Remodel the Hepatic Lipidome and Produce Hepatic Ketones in Obese Mice, Improving Liver Function
    Justin F. Creeden — Neurosciences, University of Toledo College of Medicine and Life Sciences
    2:30 PM - 2:45 PM

  • Abstract 2 - PPARĪ± in Osteocytes Regulates Marrow Fat
    Amit S. Chougule — Bone and Joint Center, Henry Ford Health System
    2:45 PM - 3:00 PM

  • Abstract 3 - PXR and Metabolism
    Taosheng Chen — Chemical Biology and Therapeutics, St. Jude Children's Research Hospital
    3:00 PM - 3:15 PM

  • Abstract 4 - Early Life Stress Enhances the Obesogenic Response in Female Mice Via Mineralocorticoid Receptor (MR) Signaling
    Jacqueline Renee Leachman — Pharmacology & Nutritional Sciences, University of Kentucky
    3:15 PM - 3:30 PM

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