APS Annual Meeting at Experimental Biology

Nuclear Receptors and Metabolism

Featured Topic — Wednesday, April 28, 2021 — 2:00 PM - 3:30 PM — Virtual Session, Room APS-9
Endocrinology and Metabolism Section — Chair: Terry D. Hinds — Co-Chair: David E. Stec

Nuclear receptors (NRs) are transcription factors that, over the past two decades, have emerged as significant components in nutrient sensing. Several NRs are activated by natural ligands, including fatty acids, cholesterol, bilirubin, bile acids, eicosanoids, and others. Activation of some NRs induces fat storage, while others reduce fat accumulation. The balance of the NR signaling is essential for homeostasis, and imbalances in NR signaling may underlie the development of obesity and metabolic dysfunction. This session will discuss NRs and metabolic control and how they affect disorders such as obesity, fatty liver, type II diabetes, and other metabolic complications.


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    Walter Wahli — Center for Integrative Genomics, University of Lausanne

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