APS Annual Meeting at Experimental Biology

Metabolic Adaptation and Heterogeneity in Physiology and Disease

Featured Topic — Wednesday, April 28, 2021 — 10:00 AM - 11:30 AM — Virtual Session, Room APS-9
Endocrinology and Metabolism Section — Chair: Alexander Pfeifer — Co-Chair: Shingo Kajimura

Metabolic organs possess the high adaptive capacity to control their function in response to a variety of hormonal and external changes, such as nutritional levels, temperatures, and oxygen levels. As an example, adipose tissues dynamically remodel their cellular size and composition through a broad spectrum of mechanisms ranging from regulation of lipolysis, angiogenesis and adipogenesis to thermogenesis (e.g. beige adipocyte biogenesis). Such metabolic adaptation plays a central role in systemic energy homeostasis and a defect in the adaptive pathways is closely associated with insulin resistance, dyslipidemia, chronic inflammation, and mitochondrial dysfunction. Emerging evidence also suggests that metabolic organs are composed of heterogeneous cell populations. However, it remains poorly understood regarding the primary cell types through which metabolic stress triggers maladaptive processes.  Thus, learning molecular and cellular mechanisms of metabolic adaptation and heterogeneity in metabolic organs may lead to new therapeutic targets to alleviate metabolic disorders that may stem from maladaptive responses.  In this session, we would like to discuss our current understanding of diverse adaptive mechanisms in metabolic organs and further discuss possible strategies to improve metabolic health.


  • Introductions
    Chairs, Dr. Pfeifer and Dr. Kajimura —
    10:00 AM - 10:02 AM

  • Metabolic Flexibility of the Adipocyte – Impact on Diabetes
    Philipp Scherer — Touchstone Diabetes Center, The University of Texas Southwestern Medical Center
    10:02 AM - 10:30 AM

  • Abstract 1 - Regulation of Brown Adipose Tissue and beige fat by the Adenosine A2B Receptor   8.5.5
    Thorsten Gnad — Pharmacology & Toxicology, University of Bonn
    10:30 AM - 10:45 AM

  • Abstract 2 - Intermittent Ambient Cold Exposure Is Not an Effective Obesity Treatment in Mice Housed at Thermoneutrality
    Greg L. McKie — Human Health and Nutritional Sciences, University of Guelph
    10:45 AM - 11:00 AM

  • Abstract 3 - Proinflammatory CD8+ T-Cells Contribute to Age-Related Glucose Intolerance
    David J. Buckley — The University of Texas at Arlington
    11:00 AM - 11:15 AM

  • Abstract 4 - Senolytic Drugs, Dasatinib and Quercetin, Attenuate Adipose Tissue T Lymphocyte Infiltration and Improve Metabolic Function in Old Mice
    Md Torikul Islam — Nutrition and Integrative Physiology, University of Utah
    11:15 AM - 11:30 AM

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