APS Annual Meeting at Experimental Biology



Urinary MicroRNAs in Kidney Disease

Symposium — Tuesday, April 27, 2021 — 10:00 AM - 11:30 AM — Virtual Session, Room APS-5
Renal Section — Chair: Lilach O. Lerman — Co-Chair: John (Cijang) He

MicroRNAs (miRNAs) are small, noncoding single-stranded RNA’s that modulate physiological and pathological processes by targeting gene expression.Mounting evidence implicates miRNAs in various biological processes, such as cell proliferation, differentiation, and cancer. Dysregulation of miRNAs expression patterns in the urine has been associated with various forms of kidney disease and hypertension. Urinary microRNA often originate from primary kidney cells and urinary tract cells. Although their validity as biomarkers for kidney disease has not been fully established, studies have been applying analysis of miRNAs in the urine in an attempt to detect and monitor acute and chronic renal diseases. Because appreciation of the significance of miRNAs in the renal field is on the rise, understanding miRNAs pathways that regulate renal physiology and pathophysiology is becoming critically important. This session aims to overview recent data obtained in this field of research. New developments in the use of miRNAs as biomarkers and/or therapeutic agents may help manage and contain kidney disease in affected subjects.

Speakers

  • Introduction
    Lilach Lerman — Mayo Clnic
    10:00 AM - 10:05 AM

  • MicroRNAs as Regulators of Glomerular Function
    Ariela Benigni — Istituto di Ricerche Farmacologiche, Istituto di Ricerche Farmacologiche “Mario Negri”
    10:05 AM - 10:30 AM

  • Exosomal MicroRNA in Patients with Obesity

    Soon Hyo Kwon — Nephrology, Soonchunhyang Medical College
    10:30 AM - 10:45 AM

  • Mitochondrial DNA and MicroRNA’s in the Metabolic Syndrome
    Alfonso Elrin — Nephrology and Hypertension, Mayo Clinic
    10:45 AM - 11:00 AM

  • MicroRNA Signature in Chronic Kidney Disease

    Dominic Raj — Division of Renal Diseases and Hypertension, George WashingtonUniversity School of Medicine
    11:00 AM - 11:25 AM

  • Conclusion
    Lilach Lerman — Mayo Clinic
    11:25 AM - 11:30 AM




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