Urinary Micro-RNAs in Kidney Disease

Symposium — Tuesday, April 27, 2021 — 10:00 AM - 11:30 AM — , Room APS-5
Renal Section — Chair: Lilach O. Lerman — Co-Chair: John (Cijang) He

MicroRNAs (miRNAs) are small, noncoding single-stranded RNA’s that modulate physiological and pathological processes by targeting gene expression.Mounting evidence implicates miRNAs in various biological processes, such as cell proliferation, differentiation, and cancer. Dysregulation of miRNAs expression patterns in the urine has been associated with various forms of kidney disease and hypertension. Urinary microRNA often originate from primary kidney cells and urinary tract cells. Although their validity as biomarkers for kidney disease has not been fully established, studies have been applying analysis of miRNAs in the urine in an attempt to detect and monitor acute and chronic renal diseases. Because appreciation of the significance of miRNAs in the renal field is on the rise, understanding miRNAs pathways that regulate renal physiology and pathophysiology is becoming critically important. This session aims to overview recent data obtained in this field of research. New developments in the use of miRNAs as biomarkers and/or therapeutic agents may help manage and contain kidney disease in affected subjects.

Speakers

• MicroRNAs as Regulators of Glomerular Function
  Ariela Benigni — Istituto di Ricerche Farmacologiche, Istituto di Ricerche Farmacologiche “Mario Negri”


• Exosomal microRNA in in Patients with Obesity
  Soon Hyo Kwon — Nephrology, Soonchunhyang Medical College


• Mitochondrial DNA and MicroRNA’s in the Metabolic Syndrome
  Alfonso Elrin — Nephrology and Hypertension, Mayo Clinic


• MicroRNA signature in chronic kidney disease
  Dominic Raj — Division of Renal Diseases and Hypertension, George WashingtonUniversity School of Medicine


• Session Chair
  Lilach O. Lerman — Nephrology and Hypertension, Mayo Clinic


• Session Co-Chair
  John (Cijang) He — Medicine, Mount Sinai