Pathogenic Mechanisms of Electronic Cigarette or Vaping Associated Lung Injury (EVALI)

Nonfunded Featured Topic — Friday, April 30, 2021 — 10:00 AM - 11:30 AM — Virtual Session, Room APS-12
Respiration Section — Chair: Xinping Yue — Co-Chair: Denise Al Alam

There is an emerging appreciation of E-cigarettes and/or vaping as a novel cause of acute lung injury (EVALI).  This Featured Topic, which is a refinement of a Scientific Symposium previously programmed for the 2020 EB meeting, seeks to incorporate state-of-the-art mechanistic studies of EVALI.  Of note, this Featured Topic is designed for flexibilty to incorporate studies of COVID-19, which may be shaped by antecedent inhalational nicotine/vaping. 

Speakers

• Introductions
  Chairs, Dr. Xinping Xue and Dr. Denise Al Alam —
  10:00 AM - 10:02 AM


• Electronic-Cigarette Aerosol Exposures Cause Adverse Pulmonary Effects in Vitro and in Vivo
  Alexandra Noel — Comparative Biomedical Sciences, Louisiana State University School of Veterinary Medicine
  10:02 AM - 10:25 AM


• Moderated Discussion
  Xinping Yue — Physiology, Louisiana State University Health Science Center
  10:25 AM - 10:30 AM


• Abstract 1 - Loss of Mitochondrial Adenine Nucleotide Translocase (ANT1) Regulates Cellular Senescence and Protects against Chronic Obstructive Pulmonary Disease
  Corrine R. Kliment — Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh College of Medicine
  10:30 AM - 10:45 AM


• Abstract 2 - Cigarette or E-Cigarette Content Alters Autophagy and Permeability of Lung Endothelium 
  Mounica Bandela — Bioengineering, University of Illinois at Chicago
  10:45 AM - 11:00 AM


• Abstract 3 - Acetaldehyde in E-Cigarette Aerosol and Cigarette Smoke Exacerbate Pulmonary Microvascular Endothelial Dysfunction in ALDH2*2 Mice
  Xuan Yu — Anesthesiology, Perioperative and Pain Medicine, Stanford University
  11:00 AM - 11:15 AM


• Abstract 4 - Toxicological Assessment of E-Cigarette or Vaping Product Use Associated Lung Injury (EVALI) Cartridges and Constituents
  Thivanka Muthumalage — Environmental Medicine, University of Rochester Medical Center
  11:15 AM - 11:30 AM