APS Annual Meeting at Experimental Biology

Above and Beyond the CPG: Influence of Higher Brain Centers on Breathing

Nonfunded Featured Topic — Friday, April 30, 2021 — 2:00 PM - 3:30 PM — Virtual Session, Room APS-12
Respiration Section — Chair: George Richerson — Co-Chair: Kevin J Cummings

While the essential neurocircuitry responsible for basic respiratory rhythmogenesis and patterning resides in the brainstem, new data are emerging indicating that regions of the midbrain and forebrain can powerfully modulate breathing under a variety of conditions. For example, several hypothalamic nuclei, including the lateral, perifornical, and paraventricular hypothalamus contribute to eupnea and the hypoxic and hypercapnic ventilatory responses. The midbrain periaqueductal gray can also modulate breathing in response to visual, auditory, and emotional cues. Dr. George Richerson from University of Iowa will be the featured speaker and will present data showing that amygdala is key for the apnea that contributes to sudden unexpected death in epilepsy (SUDEP). This Featured Topic is open to all research that focuses on novel neurophysiological mechanisms by which higher brain centers control breathing in normal and pathophysiological conditions.


  • Introductions
    Kevin J. Cummings — Biomedical Sciences, University of Missouri
    2:00 PM - 2:02 PM

  • Central Apnea without Dyspnea by Activation of the Amygdala: Role in SUDEP
    George Richerson — Neurology, University of Iowa
    2:02 PM - 2:25 PM

  • Discussion
    Kevin J. Cummings — Biomedical Sciences, University of Missouri
    2:25 PM - 2:30 PM

  • Abstract 1 - Role of Seizure Activity within the Parafascicular Nucleus in Cessation of Respiratory Rhythm and Potentially SUDEP
    Andrew Tryba — Pediatric Neurology, University of Chicago
    2:30 PM - 2:45 PM

  • Abstract 2 - Orexin Facilitates the Hypoxic Ventilatory Response in Rats
    Richard Spinieli — Biomedical, University of Missouri
    2:45 PM - 3:00 PM

  • Abstract 3 - The Role of Dorsomedial Hypothalamic LepRb-expressing Neurons in the Control of Respiratory Motor Output
    Jeehaeh Do — Northwestern University
    3:00 PM - 3:15 PM

  • Abstract 4 - Forebrain Response to Breathing in Humans during Awake and Unconscious States
    Ariane E. Rhone — Neurosurgery, University of Iowa
    3:15 PM - 3:30 PM

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