APS Annual Meeting at Experimental Biology

SARS-CoV-2: New Mechanistic Insights and the Promise of Future Treatments

Symposium — Wednesday, April 28, 2021 — 10:00 AM - 11:30 AM — , Room APS-12
Respiration Section — Chair: Julie A. A Bastarache — Co-Chair: Frank Jacono

The year 2020 will forever be remembered as the year of the SARS-CoV-2/COVID-19 pandemic. While this has been a devastating time for all of humanity, it has also been an unprecedented time for scientists marked by remarkable progress at an amazing pace. In this session, we will highlight cutting edge work from three leaders in the field. Mark Denison has been leading the charge in both vaccine development and novel antiviral treatment approaches. He will highlight recent work on antivirals, focusing on mechanisms of viral inhibition in the respiratory epithelium. Stanley Perlman is an international expert on respiratory disease caused by pathogenic human coronaviruses, including SARS-CoV, SARS-CoV-2, and MERS-CoV. He will discuss recent findings on the pathogenesis of COVID-19 on the lungs and brain. Finally, Fadi Xu is an international expert on pathogenic viral infection of brainstem respiratory neurons. He will discuss his work on the impact of neural infection by lethal avian influenza A (H5N1) virus on the control of breathing, which will provide necessary insights into potential contributory neurological mechanisms in silent pneumonia, ARDS, and respiratory failure in COVID19. This session will be of interest to lung biologists, neurobiologists, virologists and anyone interested in SARS-CoV-2 infection and COVID-19 etiology, progression and potential therapeutics. Attendees of this session will develop a deep understanding of mechanisms of viral pathophysiology and treatment approaches.


  • Pathogenesis of COVID-19 in the lungs and brain
    Stanley Perlman — Department of Microbiology and Immunology, and Department of Pediatrics, University of Iowa

  • Impacts of Neural Infection by Lethal Avian Influenza A (H5N1) Virus on Control of Breathing
    Fadi Xu — Lovelace Respiratory Research Institute

  • The therapeutic promise of novel antivirals for SARS-CoV2
    Mark Denison — Department of Pediatrics, Vanderbilt University Medical Center

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