APS Annual Meeting at Experimental Biology

Exercise and the Kidneys: Regulation in Health and Disease

Symposium — Thursday, April 29, 2021 — 2:00 PM - 3:30 PM — Virtual Session, Room APS-8
Environmental and Exercise Physiology Section — Chair: Justin Sprick — Co-Chair: Rachel Drew

While the responses and adaptations that occur with exercise have been well characterized for most tissues, one organ system that has received considerably less attention is the kidneys. The following physiological mechanisms and phenomena have been identified in the relationship between exercise and renal physiology: 1) While kidneys receive ~20% of cardiac output at rest, this proportion is greatly decreased during exercise due to the redistribution of blood flow away from the kidneys and towards the working skeletal muscles; 2) Differences in neurovascular responses involving the kidneys during exercise may highlight an important mechanism contributing to differences in blood pressure regulation between populations (i.e. differences with age); 3) Chronic kidney disease (CKD) patients exhibit pronounced exercise intolerance and abnormal neurocirculatory control during exercise. The goal of this symposium is to provide a comprehensive update regarding the neurovascular responses involving the kidneys that occur during both an acute bout of exercise as well as the adaptations that result from regular exercise training in health and disease. To address this, this symposium brings together four investigators from diverse backgrounds with expertise in varying aspects of exercise and renal physiology in humans.


  • The Impact of Aging on Renal Blood Flow During Acute Exercise: Contribution of the Exercise Pressor Reflex
    Rachel Drew — University of Massachusetts Boston

  • Exercise to Prevent Cardiac Dysfunction in Chronic Kidney Disease
    Erin Howden — Baker Heart and Diabetes Institute

  • Vascular Function in Chronic Kidney Disease: A Target for Aerobic Exercise
    David G Edwards — University of Delaware

  • Exercise for Hemodialysis Patients: Challenging the Status Quo
    Kenneth Wilund — University of Illinois at Urbana-Champaign

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