Understanding and Countering Opioid-Induced Respiratory Depression
Featured Topic — Wednesday, April 28, 2021 — 2:00 PM - 3:30 PM — Virtual Session, Room APS-12
Respiration Section — Chair: Erica Levitt — Co-Chair: Gaspard Montandon
Every day 130 Americans die from opioid overdose, totaling over 40,000 deaths per year. A large driver of the opioid crisis is the exponential increase in overdoses caused by fentanyl. The cause of death from opioid overdose is respiratory failure, yet the mechanisms of opioid-induced respiratory depression are poorly understood. This Featured Topic symposium will provide an update on progress toward understanding the mechanisms underlying opioid-induced respiratory depression, and address experimental approaches to counter overdose. Erica Levitt will introduce the topic and provide an update on cellular and circuit level mechanisms in the Kölliker-Fuse and parabrachial complex leading to respiratory dysfunction by opioids. Additional abstracts will be selected that discuss opioid actions or countering mechanisms in the brain, spinal cord and/or periphery.
Speakers
- Introductions
Gaspard Montandon — Division of Respirology, Department of Medicine, University of Toronto
2:00 PM
- 2:02 PM
- Pontine Mechanisms of Opioid-Induced Respiratory Depression
Erica Levitt — Department of Pharmacology & Therapeutics, University of Florida
2:02 PM
- 2:15 PM
- Abstract 1 - Inspiratory and Phase-Spanning Dorsolateral Pontine Neurons Are Silent During Fentanyl-Induced Apnea
Sandy Saunders — Pharmacology and Therapeutics, University of Florida
2:15 PM
- 2:30 PM
- Abstract 2 - Rhythmogenic States of the Respiratory Network Reveal Differential Opioid Sensitivity
Nicholas J. Burgraff — Seattle Children's Research Institute
2:30 PM
- 2:45 PM
- Abstract 3 - Investigating Opioid-induced Respiratory Depression and Analgesia Using Larval Zebrafish
Shenhab Zaig — Keenan Research Centre for Biomedical Science, St. Michael's Hospital
2:45 PM
- 3:00 PM
- Abstract 4 - The Ability of Fentanyls and Other Opioids to Increase EMG Amplitude in Respiratory Muscles Correlates with their Agonist Efficacy
Damiana Cavallo — University of Bristol
3:00 PM
- 3:15 PM
- Abstract 5 -Intranasal Leptin Prevents Opioid-induced Deaths in Mice
Carla Freire — Johns Hopkins University
3:15 PM
- 3:30 PM