APS Annual Meeting at Experimental Biology

Metabolism and Aging in Acute and Chronic Lung Diseases

Symposium — Tuesday, April 27, 2021 — 10:00 AM - 11:30 AM — , Room APS-12
Respiration Section — Chair: Samantha Yeligar — Co-Chair: Ana Mora

Metabolic dysregulation and aging are hallmarks of the pathogenesis and progression of acute and chronic lung diseases. Recent studies suggest that metabolic reprogramming, often to re-establish cellular homeostasis, falters with aging which may be particularly important in chronic lung diseases like pulmonary fibrosis. Chronic obstructive pulmonary disease is also impacted by age-related immune cell dysfunction. Further, human lungs of different ages demonstrate alterations in alveoli. This symposium will present the latest research on lung metabolism and aging with talks from established investigators who continue to define the key metabolic pathways associated with acute and chronic lung diseases. Understanding the molecular mechanisms that characterize lung diseases provide invaluable opportunities to identify novel therapeutic strategies that could mitigate metabolic derangements and aging phenotypes. 


  • Introduction
    Samantha Yeligar — Department of Medicine, Emory University
    10:00 AM - 10:05 AM

  • Translating Biomarkers of Aging Hallmarks for Use in Early Pulmonary Fibrosis
    Jason Sanders — Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School
    10:05 AM - 10:30 AM

  • Iron and Mitochondria in the Susceptibility, Pathogenesis and Progression of COPD
    Suzanne Cloonan — Weill Cornell Medicine and Trinity College
    10:30 AM - 10:55 AM

  • Optical Studies of Alveoli in Human Lungs of Different Ages
    Jahar Bhattacharya — Medicine, Columbia University Medical Center
    10:55 AM - 11:20 AM

  • Conclusion
    Ana Mora — Department of Medicine, Ohio State University
    11:20 AM - 11:30 AM

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