APS Annual Meeting at Experimental Biology

Reconciling Omics with Tissue Function: The Future of Physiology?

Symposium — Thursday, April 29, 2021 — 4:00 PM - 5:30 PM — Virtual Session, Room APS-1
Experimental Biology Symposium Series — Chair: Nirupama Ramkumar — Co-Chair: Markus Rinschen

With the advent of the omics, an ever increasing amount of data is generated from tissue in health and disease. Our ability to generate transcriptome, proteome and metabolome data has largely outperformed our ability to understand them, and to generate physiologically meaningful conclusions from them. The main goal of this symposium is to give an overview of how to connect physiology to the emerging omics data, in particular the omics that are closely regulated to the phenotype, i.e. the proteome and the metabolome. This focused area of research has the potential to cut across multiple research areas and be of interest to a broad audience attending EB. Moreover, the direct physiological relevance of many omics studies is unclear, and the datasets acquired are often not linked to organismal or organ physiology, thereby questioning the role of physiology in the age of “big data”. Finally, the development of single cell sequencing, and sensitive proteomics and metabolomics tools has propelled the field across manydisciplines, leaving a gap between the acquisition of omics data and the ability to understand them, quantitatively predict behavior, and modulate the phenotype of the system by genetic or pharmacological interventions. While these questions can be primarily seen as an academic problem, a solution may be of interest to a variety of disciplines, including the emerging area of precision medicine. We have invited a wide set of speakers across the spectrum of physiology and omics, with a focus on cardiovascular and renal scientists, but this topic is also of potential relevance to a wide variety of sections interested in cell physiology, genomics and translational physiology.


  • Introduction
    Nirupama Ramkumar — Nephrology and Hypertension, University of Utah
    4:00 PM - 4:05 PM

  • Kidney Organoid Omics - What Can We Learn About Development, Disease and Physiology?
    Jennifer Leigh Harder — Internal Medicine, University of Michigan
    4:05 PM - 4:30 PM

  • Metabolomic Activity to Determine Kidney Tubule Function
    Markus Rinschen — Biomedicine, Aarhus University
    4:30 PM - 4:55 PM

  • The Extracellular Matrix Proteome in Cardiac Physiology
    Merry L. Lindsey — Cellular & Integrative Physiology, University of Nebraska Medical Center
    4:55 PM - 5:20 PM

  • Conclusion
    Nirupama Ramkumar — Nephrology and Hypertension, University of Utah
    5:20 PM - 5:30 PM

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