APS Annual Meeting at Experimental Biology

Multiscale Modeling to Understand Human Pathophysiology

Symposium — Wednesday, April 28, 2021 — 4:00 PM - 5:30 PM — Virtual Session, Room APS-1
Experimental Biology Symposium Series — Chair: Robert L. Hester — Co-Chair:

Multiscale simulation of human physiology has provided unique insight into understanding of human pathophysiology. Mechanistic physiological modeling relies extensively on experimental data from both clinical and animal studies and is currently being used for both drug and medical device development. The speakers in this session will address three areas of human disease using mathematical modeling to understand the integrative aspect of the pathophysiology. 1) SGLT2 inhibitors are newest class of anti-hyperglycemic drugs for diabetes mellitus treatment. The role of sex and existing comorbidities on the efficacy and benefit of SGLT2 inhibitor therapy is currently unclear. Dr. Layton uses computer simulation to understand these potential roles. 2) Heart failure continues to be a deadly and prevalent disease. There are predominately two forms of heart failure, heart failure with reduced Ejection Fraction (HF-rEF) and heart failure with preserved Ejection Fraction (HF-pEF). Dr. Hallow uses a cardiorenal model to realistically replicate heart failure and understand interactions between renal and cardiac function with and without therapy. 3) African Americans have a disproportionately greater prevalence and severity of hypertension as well as poorer control of blood pressure as compared to the white population. Dr. Clemmer will present his work on simulating a virtual African American population with heterogeneous modalities of hypertension and predicting physiological mechanisms of non-response to antihypertensive therapy.


  • Introduction
    Robert L. Hester — Physiology, University of Mississippi Medical Center
    4:00 PM - 4:05 PM

  • Optimizing Diabetes Treatment Using SGLT2 Inhibitors Based on the Patient's Sex and Comorbidities
    Anita Layton — Mathematical Biology and Medicine, University of Waterloo
    4:05 PM - 4:30 PM

  • Understanding Heart Failure Pathophysiology and Therapeutic Mechanisms Through Integrated Mathematical Modeling of Cardiorenal Function
    Melissa K. Hallow — College of Public Health, University of Georgia
    4:30 PM - 4:55 PM

  • An in Silico Analysis Using Physiological Models of Hypertensive African Americans
    John Clemmer — Physiology and Biophysics, University of Mississippi Medical Center
    4:55 PM - 5:20 PM

  • Conclusion
    Robert L. Hester — Physiology, University of Mississippi Medical Center
    5:20 PM - 5:30 PM

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