APS Annual Meeting at Experimental Biology

Mitophagy in Cellular Homeostasis

Symposium — Tuesday, April 27, 2021 — 4:00 PM - 5:30 PM — Virtual Session, Room APS-1
Experimental Biology Symposium Series — Chair: Zhipeng (Toby) Tao — Co-Chair: My N. Helms

Mitochondrial quality control is central to cellular function and homeostasis. It is well accepted that aged or dysfunctional mitochondria are cleared by selective autophagy (mitophagy) to maintain homeostasis. However, the exact mechanisms remain incompletely understood. Emerging evidence suggests that mitophagy may play tissue-dependent roles and, interestingly, it may remove healthy mitochondria to redirect cell differentiation or trans-differentiation. Recent studies also identified novel role of classic mitochondrial proteins (e.g., adenine nucleotide translocator) in mitophagy regulation. This Symposium is to bring together leading scientists and peer researchers in the field, presenting the cutting-edge research, discussing outstanding questions to be addressed in the following years, and providing a forum where investigators may interact and initiate interdisciplinary collaborations.


  • Introduction
    Zhipeng (Toby) Tao — Massachusetts General Hospital, Harvard Medical School
    4:00 PM - 4:05 PM

  • Mitophagy Pathways in Adipose Cells
    Shingo Kajimura — Cell and Tissue Biology, University of California San Francisco
    4:05 PM - 4:30 PM

  • Novel Mechanisms of Mitochondrial Quality Control 
    Asa Gustafsson — Skaggs School of Pharmacy and Pharmaceutical Science, University of California San Diego
    4:30 PM - 4:55 PM

  • FoxO1 in Mitochondrial Homeostasis
    Zhiyong "Drew" Cheng — Food Science and Human Nutrition, University of Florida Gainesville
    4:55 PM - 5:20 PM

  • Conclusion
    My N. Helms — Internal Medicine, University of Utah School of Medicine
    5:20 PM - 5:30 PM

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