APS Annual Meeting at Experimental Biology

Recent Advances into the Molecular Mapping of Respiratory Circuits

Featured Topic — Wednesday, April 28, 2021 — 4:00 PM - 5:30 PM — Virtual Session, Room APS-12
Respiration Section — Chair: Russell Ray — Co-Chair: Shahriar SheikhBahaei

This Featured Topic is proposed to cover the most up to date genetic techniques used in control of breathing circuit mapping. Speakers may be selected to cover areas of genetically engineered mouse and rat lines, utilization of viral vectors for local, retrograde, anterior grade mapping, Cas9 induced somatic mutations, single cell RNA Seq approaches and Patch-Seq. The focus is expected to be on either novel technical innovations or new approaches to utilize established resources and techniques. The keynote speaker, Dr. Douglas Bayliss, is world renowned control of breathing investigator that has utilized may of the above techniques in his work on mapping respiratory chemosensory circuits. The remaining presentations will be selected from the submitted abstracts. The highlighted tools and approaches for this session are growing in popularity but there is limited awareness surrounding the availability of these resources, how they are being used, and many of the caveats and limitations associated with them. A featured topic would do much to expand the field’s utilization of novel genetics tools in respiratory circuit mapping.


  • Introductions
    Russell Ray — Department of Neuroscience, Baylor College of Medicine
    4:00 PM - 4:02 PM

  • Molecular and Cellular Mechanisms of Respiratory Chemoreceptor Function
    Doug A Bayliss — Pharmacology, University of Virginia
    4:02 PM - 4:25 PM

  • Moderated Discussion
    Russell Ray — Department of Neuroscience, Baylor College of Medicine
    4:25 PM - 4:30 PM

  • Abstract 1 - The Role of Noradrenergic and Glutamatergic Signaling in Noradrenergic Neurons in Respiratory Control
    Yuan Chang — Neuroscience, Baylor College of Medicine
    4:30 PM - 4:45 PM

  • Abstract 2 - FoxP2 Cells in the Lateral Parabrachial Area May Drive Respiratory Responses to Hypercapnia
    Satvinder Kaur — Neurology, Beth Israel Deaconess Medical Center
    4:45 PM - 5:00 PM

  • Abstract 3 - Selective Inhibition of Prebotzinger Neurons Projecting to the Facial Nucleus Decreases Nasofacial Activity without Affecting Breathing
    Mariana Del Rosso de Melo — Physiology, University of Melbourne
    5:00 PM - 5:15 PM

  • Abstract 4 - Patch-to-Seq Reveals Unique Transcriptomic Profiles of Chemosensitive Serotonergic Neurons
    Gary Mouradian — Medical College of Wisconsin
    5:15 PM - 5:30 PM

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