APS Annual Meeting at Experimental Biology



Novel Mechanisms and Therapeutic Targets for Vascular Aging

Symposium — Friday, April 30, 2021 — 10:00 AM - 11:30 AM — , Room APS-8
Physiologists in Industry Committee — Chair: Douglas Seals — Co-Chair: Kerrie Moreau

Cardiovascular diseases (CVD) remain the leading causes of morbidity and mortality in the U.S. and otherdeveloped/developing societies. Advancing age is by far the strongest risk factor for CVD. Aging increases our risk of CVD in part via direct effects on the heart and by increasing systolic blood pressure. However, the major driver of increased CVD risk with aging is arterial dysfunction, most prominently microvascular and macrovascular endothelial dysfunction and arterial stiffening. These and other features of vascular aging (arterial aging) also play a major role in many other common disorders of age from dementia to chronic kidney disease to exercise intolerance. It is well established that age associatedvascular dysfunction is linked to oxidative stress and inflammation. However, the biological and environmental factors and molecular and cellular signaling mechanisms by which aging induces and sustains arterial dysfunction areincompletely understood.This symposium will provide a timely update of this important biomedical research topic. The speakers will present observations made at levels from cell culture to mice to healthy humans and patients with CVD using an array of innovative translational research approaches. The speaker panel includes a diverse mix of female and male investigators ranging from postdoctoral to mid-career to senior established scientists. Emphasis will be placed on mechanisms viewed as therapeutic targets leading to novel preventive and treatment strategies, including implications for women’s CV health. Speaker Profiles: Lacy M. Alexander , PhD, is an Associate Professor at Penn State University, University Park, PA. Her research utilizes the human cutaneous circulation to investigate mechanisms of microvascular dysfunction with human aging and other conditions contributing to accelerated cardiovascular risk, including hypertension and hypercholesterolemia. Vienna Brunt , PhD, is a Senior Postdoctoral Fellow in Integrative Physiology at the University of Colorado Boulder. Her recent work has focused on the mechanistic role of the gut microbiome in modulating vascular function with aging and how the gut microbiome and adverse gut-derived metabolites can be targeted to improve vascular health. Anthony (Tony) Donato , PhD, is an Associate Professor of Medicine at the University of Utah and GRECC Research Investigator at the VA Medical Center in Salt Lake City. His research targets the basic cellular and molecular mechanisms of arterial dysfunction with aging, including genomic instability, specifically telomere dysfunction and cellular senescence. Kerrie Moreau , PhD, is Professor of Geriatric Medicine at the University of Colorado Anschutz Medical Campus and anEastern Colorado Health Care System GRECC Research Health Scientist. She is interested in how changes in gonadal hormones with reproductive aging in women and men contribute to vascular aging and adaptations to therapeutic interventions.

Speakers

  • Symposium Introduction
    Douglas Seals — Integrative Physiology, University of Colorado Boulder

  • Novel Mechanisms and Intervention Strategies to Mitigate Microvascular Dysfunction in Aging
    Lacy Alexander — Kinesiology, Penn State University

  • Role of the Gut Microbiome in Vascular Aging
    Vienna Brunt — Integrative Physiology, University of Colorado Boulder

  • Arterial Senescence and Telomere Dysfunction: Implications for Arterial Aging
    Anthony Donato — GRECC, University of Utah and VA Medical Center

  • Mechanistic Insight into the Critical Window for Vascular Aging in Women
    Kerrie Moreau — Center for Women's Health Research, University of Colorado Anschutz Medical Campus

  • Session Chair
    Douglas Seals — Integrative Physiology, University of Colorado Boulder

  • Session Co-Chair
    Kerrie Moreau — Center for Women's Health Research, University of Colorado Anschutz Medical Campus




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