APS Annual Meeting at Experimental Biology



Mighty Mitochondria: From Calcium Sparks to Healthy Longevity

Symposium — Tuesday, April 27, 2021 — 10:00 AM - 11:30 AM — Virtual Session, Room APS-3
Cell and Molecular Physiology Section — Chair: B. Rita Alevriadou — Co-Chair: Jeffrey S. Isenberg
AJP-Cell Physiology

Mitochondria oxidize various energy substrates for the production of ATP, the universal energy currency of all cells. Mitochondrial dysfunction has been reported as causative or a consequence of almost every single pathological human disease and condition, from cardiovascular to neurodegenerative. A better understanding of mitochondrial energy transduction, regulation of calcium transport, and production of reactive oxygen species, has the potential to provide approaches to preserve survival in cells and organisms and delay aging. Thus, it is important to understand the functional consequences of mitochondrial (and endoplasmic reticulum) stress responses at each of the cellular, tissue/organ, and distant organ/body systems levels. It is also essential to understand how these differ between stem vs. differentiated cells, or in young vs. aged organisms. Mitochondria-targeted therapeutic strategies from antioxidants to nutritional supplements have been tested extensively in animal models. Several have been/are currently in clinical trial (combined or not with diet and exercise regimes). These demonstrate, at least in part, promising preliminary results. The Symposium will feature three renowned leaders in mitochondrial biology and metabolism who will present their state-of-the-art basic and translational research.

Speakers

  • Mitochondrial Biogenesis and Adaptability in Sickness and in Health
    David A Stroud — Department of Biochemistry and Molecular Biology, The University of Melbourne

  • Boosting Skeletal Muscle Mitochondrial Energetics to Counter Diet-Resistant Obesity
    Mary-Ellen Harper — Department of Biochemistry, Microbiology and Immunology, University of Ottawa

  • Targeting Cardiolipin to Restore Cellular Bioenergetics for Healthy Aging
    Hazel H Szeto — Social Profit Network




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