APS Annual Meeting at Experimental Biology

Methods to Assess Blood Pressure Regulation in Humans and in Animal Models

Workshop — Wednesday, April 21, 2021 — 11:00 AM - 1:00 PM — Virtual Session, Room Zoom Meeting
Techniques Workshop Program — Chair: Nina Stachenfeld — Co-Chair: Lacy Alexander

Hypertension is a primary contributor to cardiovascular disease and stroke, the two leading causes of death in the United States. Therefore, the measurement of blood pressure and methods to allow us to understand the regulation of blood pressure, have primary roles in both human and animal physiology. The methods we use to understand blood regulation in both humans and in animal models have evolved dramatically over the last decade. This workshop will address the gold standard and innovative methods used the measurement and analysis of blood pressure regulation in physiological research. We will begin our session with Dr. Noha Shawky, who will describe in detail the use of radiotelemetry to measure blood pressure measurement in freely-moving rats. This method is the gold standard blood pressure measurement in freely-moving rats, is vital for understanding both long and short-term changes in blood pressure, and is required by most grant reviewers. Dr. Lacy Alexander will describe the use of skin microdiaylsis to address mechanisms of blood pressure regulation in humans. This method is an innovative method to examine blood pressure control in humans, and can be applied to many different questions in human physiology. Dr. Vaughan Macefield will address microneurography, the measurement of sympathetic nerve activity (SNA), using methods developed in his laboratory including both multi and single unit recordings, and how these methods are used to examine mechanisms regulating blood pressure in humans, including his most recent muscle SNA-fMR coupled research. Dr. Lindsea Booth will describe methods in recording cardiac and renal sympathetic nerve activity in sheep, both key contributors to blood pressure regulation and dysregulation. Thus, this workshop will showcase an exciting group of leading experts in this important and foundational aspect of human research. We also expect to see exciting new data from these scientists as they describe in detail their innovative methods.

This workshop will be held outside the EB 2021 virtual meeting platform and will be free for all, however you must register.

REGISTRATION IS REQUIRED:  https://zoom.us/meeting/register/tJAtf-mtrjsqGtXmeo5bph4bOGOTE6fwzSQf


  • Introduction
    Nina Stachenfeld — John B. Pierce Laboratory, Yale School of Medicine
    11:00 AM - 11:05 AM

  • Blood Pressure Measurement in Freely-Moving Rats by Telemetry: The Gold Standard Method
    Noha M. Shawky — Cell and Molecular Biology, University of Mississippi Medical Center
    11:05 AM - 11:30 AM

  • Use of Skin Microdialysis in Discovering Mechanisms for Blood Pressure Regulation in Humans
    Lacy Alexander — Kinesiology, The Pennsylvania State University
    11:30 AM - 11:55 AM

  • Intraneural Recordings from Postganglionic Sympathetic Axons in Awake Humans: Single-Unit Recordings and Increasing the Utility of Multi-Unit Recordings
    Vaughan G. Macefield — Physiology, University of Melbourne
    11:55 AM - 12:20 PM

  • Cardiac and Renal Sympathetic Nerve Recordings in Conscious Sheep
    Lindsea Booth — Pre-Clinical Care Unit, Florey Institute of Neuroscience and Mental Health
    12:20 PM - 12:45 PM

  • Group Discussion and Closing Remarks

    Lacy Alexander — Kinesiology, The Pennsylvania State University
    12:45 PM - 1:00 PM

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