APS Annual Meeting at Experimental Biology

Regenerative Rehabilitation: Optimizing the Functional Recovery of Skeletal Muscle (partnered with AR3T)

Symposium — Thursday, April 29, 2021 — 10:00 AM - 11:30 AM — Virtual Session, Room APS-3
Muscle Biology Group — Chair: Sarah M. Greising — Co-Chair: Jarrod A. Call

Fundamental to the physiology of skeletal muscle is its “plasticity”, or the concept that muscle maintains an ability to adapt to mechanical and/or chemical cues in order to improve functional capacity. This is foundational to all exercise and rehabilitation, as various stimuli are expected to impart positive changes in the health of the muscle. In addition, fundamental to the physiology skeletal muscle is an innate healing process following injury, specifically repair and regeneration through a pool of satellite cells activating and proliferating following endogenous immune responses to injury resulting in muscle fiber regeneration and a rescue to prior injury state. This symposium will focuses on conditions of skeletal muscle that have altered plasticity and/or limited to no regenerative potential and long term functional deficits, conditions that are clear targets for regenerative rehabilitation. The currently accepted field definition of regenerative rehabilitation is a therapy that: “… integrates regenerative technologies with rehabilitation clinical practices to restitute function and quality of life in individuals with disabilities due to otherwise irreparable tissues or organs damaged by disease or trauma”. The primary goal of all regenerative rehabilitation is functional restoration to a pre-morbid state, and while not limited or confined to one organ system, this symposium will focus on skeletal muscle. Specifically with speakers who cover basic, translational, and clinical aspects of regenerative rehabilitation. These speakers will discuss aspects of regenerative rehabilitation in traumatic musculoskeletal conditions, neuromuscular disorders, and pathologic conditions such as volumetric muscle loss, muscular dystrophy, and peripheral artery disease respectively. We have partnered with the Alliance for Regenerative Rehabilitation Research and Training (AR3T) for this symposium in order to educate the broader physiology field regarding current trends in regenerative rehabilitation.


  • Introduction
    Sarah M. Greising — University of Minnesota
    10:00 AM - 10:05 AM

  • Molecular Metabolism as a Nexus for Regenerative Rehabilitation
    Jarrod A. Call — Department of Kinesiology, University of Georgia
    10:05 AM - 10:30 AM

  • Developing Crisper Regenerative and Rehabilitative Therapies for Muscle Loss, in the Era of CRISPR Gene Therapies
    Joseph A. Roche — Department of Health Care Sciences, Wayne State University
    10:30 AM - 10:55 AM

  • Large Animal Modeling of Clinical Disease
    Luke P. Brewster — Emory University & Atlanta VA Medical Center
    10:55 AM - 11:20 AM

  • Conclusion
    Sarah Greising — School of Kinesiology, University of Minnesota
    11:20 AM - 11:30 AM

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