Crosstalk among Myofibers, Microvessels and Motor Nerves during Skeletal Muscle Regeneration
Symposium — Tuesday, April 9, 2019 — 8:30 AM - 10:00 AM — Convention Center, Room W311EF
Experimental Biology Symposium Series — Chair: Steven Scott Segal — Co-Chair:
Cosponsored by J. Appl. Physiol.
Skeletal muscle is essential to breathing, locomotion and energy metabolism. Myofibers are long, multinucleated cells in close apposition to microvessels. Contractile activity is initiated at neuromuscular junctions (NMJs) via axons projecting from the spinal cord and muscle blood flow increases with metabolic demand. In such manner, skeletal muscle function in daily life exemplifies dynamic interactions among motor units and their microvascular supply. What is the nature and extent of crosstalk among myofibers, microvessels and motor nerves when skeletal muscle is recovering from acute injury? The overall goal of this symposium is to develop a framework for understanding the dynamic interactions among respective tissue components during (and integral to) the regeneration of functional skeletal muscle. The abilities of myofibers to regenerate, of microvessels to proliferate and of injured motor axons to restore NMJs are well recognized. However, little is known of the nature of crosstalk between respective cell types during regeneration of the intact tissue. Injury and inflammation activate muscle stem (satellite) cells, which are intimately associated with capillaries (microvascular endothelial cells). Crosstalk between myofibers, microvessels and motor neurons during regeneration will be presented by D Cornelison (Mizzou). Structural and functional integrity of NMJs is essential to myofiber recruitment and will be presented by Steve Burden (NYU). Strategies for bioengineering new muscle to restore that lost during traumatic injury will be presented by Penney Gilbert (U Toronto). To foster crosstalk during this symposium, each speaker will consider how signaling events central to their presentation interact with those of other speakers.
- Interactions Between Myogenic, Vasculogenic, and Neuronal Cells During Skeletal Muscle Regeneration
Dawn Cornelison — Biological Sciences, Univ. of Missouri
- Mechanisms for Forming and Maintaining Neuromuscular Synapses
Steven Burden — Department of Neuroscience, Cell Biology and Physiology, New York University
- Engineering Human Skeletal Muscle in a Dish: Defining the Critical Components
Penney Gilbert — Biomaterials & Biomedical Engineering, Univ. of Toronto