2019 About APS EB 2019 Information

Oxidative Stress and Post-translational Modification of Protein Thiols in Cell Signaling

Symposium — Monday, April 8, 2019 — 8:30 AM - 10:00 AM — Convention Center, Room W311EF
Experimental Biology Symposium Series — Chair: My Nga Helms — Co-Chair: Charles Downs
Cosponsored by Physiological Reviews and AJP - Cell Physiology

Protein S-glutathionylation as a mechanism of cellular regulation under oxidative stress is a contemporary and highly relevant topic in human disorders. Under oxidative stress, the oxidized form of glutathione (GSSG) is prevalent, and known to post-translationally modify protein cysteine thiols. This focused area of research has the potential to cut across multiple research areas and be of interest to a broad audience attending EB because S-glutathionylated protein has broad biological impact in health and disease from the molecular to the cellular and organismal levels. Moreover, the molecular mechanisms responsible for regulating (reversible) protein S-glutathionylation remains unclear. Recent development in research tools for evaluating GSSG post-translational modification of protein has propelled the field across many disciplines. The goal of our proposal is to bring together experts in the area of redox sensitive post-translational modification of protein thiols, with emphasis on S-glutathionylation. We have assembled a pool of experts who could effectively address the emerging field of S-glutathionylation in pathological disorders, regulatory mechanisms (of S-glutathionylation), and the development of innovative new approaches for quantification of dynamic changes in protein S-glutathionylation. 

Speakers

  • Resin-Assisted Enrichment of Thiols as a General Strategy for Proteomic Profiling of Cysteine-Based Reversible Modification
    Wei-Jun Qian — Integrative Omics, Pacific Northwest National Laboratory

  • Glutathione and Alterations in Redox Status During Embryonic Development
    Jason Hansen — Physiology and Developmental Biology, Brigham Young University

  • Dysregulated Redox Signaling
    Yvonne Janssen -Heininger — Pathology and Laboratory Medicine, University of Vermont





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