2019 About APS EB 2019 Information

Diabetes: A Metabolic Karma

Symposium — Monday, April 8, 2019 — 8:30 AM - 10:00 AM — Convention Center, Room W311C
Translational Physiology Interest Group — Chair: Maria Alicia Carrillo Sepulveda — Co-Chair: Jian-Xiong Chen
Cosponsored by Physiological Reviews

The relationships of glycemic control over time with the development of complications have been investigated in several studies, but new areas of debate continue to arise. Does glycemic control have greater benefit when attained earlier than when attained later in the natural history of diabetes? Does glycemic control have similar benefit throughout the duration of diabetes until irreversible damage occurs, perhaps varying by organ system (neurologic, renal, retinal, cardiovascular)? It has been clearly shown that previous episodes of hyperglycemia play a key role in promoting end-organ injury in diabetes, as shown in clinical trials such as the UK Prospective Diabetes Study (UKPDS), Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation Observational Study (ADVANCEON), and the Diabetes Control and Complications Trial/ Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC). The cause of this phenomenon, known as metabolic memory, remains to be elucidated, but it appears that epigenetic pathways, including glucose-induced histone methylation, play a central role. Further delineation of these pathways and their link to not only glucose but also other factors implicated in vascular injury should lead to more rational, potentially more effective therapies to retard diabetes-associated cardiovascular disease.

Speakers

  • Redox Imbalance in the Diabetic Milieu: Novel Targets
    Karin Jandeleit-Dahm — Department of Diabetes, Monash University

  • Epigenetic Mechanisms in Diabetic Complications and Metabolic Memory
    Rama Natarajan — Department of Diabetes Complications and Metabolism, Beckman Research Institute of the City of Hope

  • Atherosclerosis Risk in Diabetes: It Begins in the Bone Marrow
    Edward A Fisher — Director, Marc and Ruti Bell Vascular Biology Program, New York University School of Medicine

  • Chair
    Maria Alicia Carrillo Sepulveda —

  • Co-chair
    Jain-Xiong Chen —





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