Mighty Concepts in Mitochondrial Biology in the Kidney
Symposium — Tuesday, April 9, 2019 — 1:30 PM - 3:00 PM — Convention Center, Room W311G
Renal Section — Chair: Sandeep K. Mallipattu — Co-Chair: Ying Li
Cosponsored by AJP - Renal Physiology
The kidney derives most of its energy from oxidative metabolism (95–99%). The kidney is only second to the heart as the organ with the highest mitochondrial abundance. Both proximal tubules and thick ascending limb, both sites of active tubular transport, are rich in mitochondria. In addition to ATP generation by oxidative metabolism, mitochondria play a significant role in the generation and detoxification of reactive oxygen species, cellular calcium homeostasis, cell survival and death (autophagy and apoptosis). They are dynamic organelles able to respond to the changing energy demands of the cells. Mitochondria play a key role in the adaptation to cellular stress in highly metabolic organs.
Significant advances in the critical role of mitochondrial biology in kidney disorders have been in the forefront in recent years. The overall objective of this session is to review the most recent concepts in mitochondrial dynamics, biogenesis, oxidative stress, mitochondrial autophagy (mitophagy) and mechanisms of energy utilization as it relates to acute kidney injury as well as progression of chronic kidney disease including diabetic kidney disease. Furthermore, understanding the mechanisms by which mitochondrial dysfunction contributes to the transition from tubular injury (secondary to ischemia and drug-induced) to interstitial fibrosis will be elucidated. There will also be a discussion on recent developments in novel therapeutic targets directed at improving mitochondrial dynamics, biogenesis, and function. The proposed speakers include a diverse group in expertise, gender and geographical location. Given the emerging literature on the significant role of tubular metabolism as the perpetuator of kidney injury, this will be a timely symposium and of great interest to wide-variety of researchers in the field of renal physiology and pathophysiology.
- Altered Mitochondrial Metabolism in AKI and CKD
Prabhleen Singh — Medicine, UC San Diego
- Role of Mitophagy (Mitochondrial Autophagy) in Kidney Disease
Zheng Dong — Cellular Biology and Anatomy, Augusta University
- Mitochondrial Function and Biogenesis in AKI
Samir Panikh — Medicine, Beth Israel Deaconess Medical Center