Neurodegeneration and Heart Failure: An intimate Connection
Symposium — Sunday, April 7, 2019 — 8:30 AM - 10:00 AM — Convention Center, Room W311H
Cardiovascular Section — Chair: Federica del Monte — Co-Chair: Loren E. Wold
Cosponsored by: AJP - Heart and Circulatory Physiology
Alzheimer’s Disease (AD) and heart failure (HF) are growing age-dependent diseases worldwide and are two of the most devastating diseases in terms of morbidity, mortality, quality of life, and health care costs. The prevalence of symptomatic HF in individuals over 65 years of age is estimated to be 6%–10% with more than 5 million individuals suffering from HF in the US and 60 million worldwide. Like AD, there are over 5.5 million cases of dementia in the United States, and 35 million worldwide. Thus, whether occurring individually or together, HF and AD are modern plagues, their potential coexistence is an alarming prospective with the aging of the population. Aging has been defined as the progressive build-up of biological changes derived from the combined effects of environmental inputs over genetic substrates. These changes are exacerbated in aging-associated diseases. Accumulation of reactive oxygen species (ROS), together with a parallel decline in antioxidant defense, has been invoked to determine the progressive loss of control over biological homeostasis in physiological aging and to contribute to the pathogenesis of HF and AD. This symposium will bring together experts in neurodegenerative diseases and cardiovascular disease to discuss the intimate brain-heart connection which could help to understand the dramatic rise in both AD and HF, with focus on specific proteins involved in the disease processes.
- Common Presenilin Genetics in AD and HF
Cristina Balla — University of Ferrara
- Brain and Cardiac Tauopathy and Aging
Onder Albayram — Beth Israel Deaconess Medical Center
- Methabolic Dysfunction in AD and HF
Monte Willis — Pathology & Laboratory Medicine, Indiana Univ. Sch. of Med.
- Diabetic Cardiomyopathy and AD: An Amylin Substrate
Florin Despa — University of Kentucky