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Thoracic and Abdominal Aortic Aneurysm: From Models and Mechanism to Clinical Trials and Therapy Updates

Symposium — Monday, April 8, 2019 — 1:30 PM - 3:00 PM — Convention Center, Room W312A
Cardiovascular Section — Chair: Zamaneh Kassiri — Co-Chair: Bo Liu
Cosponsored by: AJP - Heart and Circulatory Physiology

Aortic aneurysm is the second most frequent disease of the aorta after atherosclerosis, and the 13th cause of mortality globally. Aortic aneurysm is asymptomatic which adds a level of complexity to its detection until it is too late (it ruptures causing paralysis or death). To date, there is no direct pharmacological therapy for aortic aneurysm, and prophylactic surgical resection is used to prevent long-term complications but only when the risk of aortic events (e.g. rupture) outweighs the risk of surgery. Risk factors and prognostics for Thoracic (TAA) and abdominal aortic aneurysm (AAA) are different, and it is becoming increasingly evident that the molecular mechanism underlying these two diseases are distinct as this field of research continues to develop and new information continue to be uncovered. This symposium will showcase the research from experts in the aortic aneurysm field with diverse backgrounds and expertise. The topics that will be covered in this symposium include: 1) Clinical basis and experimental models for TAA versus AAA, 2) the mechanism underlying aortic aneurysm, and the difference between TAA and AAA, 3) recent discoveries of potential pharmacological therapies, and clinical trials for TAA and/or AAA.


  • Differential Regional Remodeling of Aortic ECM in TAA versus AAA
    Zamaneh Kassiri — Physiology, University of Alberta

  • Necroptosis in Abdominal Aortic Aneurysm: Mechanisms and Therapeutic Opportunities
    Bo Liu — Medical Research, University of Wisconsin

  • Immune Cell-Secreted Serine Proteases in Aortic Aneurysm and Rupture
    David Granville — University of British Columbia

  • Clinical Trials and Tribulation in Controlling Small AAA Growth
    Jonathan Golledge — James Cook University (Australia)

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