2019 About APS EB 2019 Information

Updating the History of Insulin; Novel Insights into Regulation of Release, Delivery, and Functions

Symposium — Monday, April 8, 2019 — 1:30 PM - 3:00 PM — Convention Center, Room W311B
History of Physiology Group — Chair: Patricia E. Molina — Co-Chair: Flavia M. Souza-Smith

The purpose of this symposium is to present an update on the history of insulin. From a scientific perspective, three experts in the field will present how insulin research has evolved with new discoveries. Dr. Naji Abumrad’s presentation will emphasize how the regulation of pancreatic beta cell insulin secretion spans the spectrum from glucose to incretins, neurons, and bariatric surgery. Focusing on how this has led to advances in treatment of diabetes and identification of novel therapeutic targets. Dr. Amira Klip’s will present the mechanisms involved in insulin transit across the microvascular endothelium and their contribution to insulin resistance. Her studies demonstrate how the steps involved in endothelial insulin transcytosis may serve as therapeutic targets in the treatment of insulin resistance. Finally, Dr. Suzanne De La Monte’s presentation will focus on the role of insulin and insulin-like growth factor resistance in relation to neurodegeneration caused by Alzheimer's disease and chronic alcohol abuse.


  • Multimodal Regulation of Beta Cell Insulin Secretion: From Nutrients to Surgery
    Naji N. Abumrad — Surgery, Vanderbilt Medical Center

  • The Journey of Insulin in the Body
    Amira Klip — Biochemistry, Paediatrics & Physiology, University of Toronto

  • Insulin Action in the Brain: Linking Neurodegeneration and Alzheimer's Disease
    Suzanne De La Monte — Pathology and Laboratory Medicine, Brown University

  • Chair
    Patricia Molina —

  • Co-Chair
    Flavia Souza-Smith —

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