Protein Degradation Mechanisms: A Compartmentalized Affair in Cardiac Muscle and Disease?
Symposium — Tuesday, April 9, 2019 — 8:30 AM - 10:00 AM — Convention Center, Room W309AB
Cardiovascular Section — Chair: Farah Sheikh — Co-Chair: Yan Liang
Cosponsored by: AJP - Heart and Circulatory Physiology
Protein turnover mechanisms, including selective autophagy, are increasingly being identified at various compartmentalized sites within the cell (sarcomere, endoplasmic reticulum, nucleus, mitochondria and intercalated disc) and dysregulation of these pathways have unique effects in heart disease and failure. This session seeks to identify and integrate their selective and reported actions in the cardiac cell and disease. This session includes 50% female speakers, mix of junior and senior investigators and good international representation.
- Critical Role of Neddylation in the Developing Heart
Huabo Su — Vascular Biology Center, Augusta University
- The Role of Muscle LIM Domain Protein in Protein Quality Control
Katja Gehmlich — Radcliffe Department of Medicine, University of Oxford
- A Novel Mechanism Impacting Cardiac Desmosomal Cell Junction Protein Degradation and Disease
Farah Sheikh — Medicine, University of California- San Diego
- Mitophagy Plays an Essential Role in Mediating Protein Quality Control in the Heart
Junichi Sadoshima — Dept of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey