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Mechanism of Hypertension-Induced Kidney Damage

Symposium — Sunday, April 7, 2019 — 3:30 PM - 5:00 PM — Convention Center, Room W311D
Renal Section — Chair: Ningjun Li — Co-Chair: Minolfa C. Prieto
Cosponsored by AJP - Renal Physiology

It is well known that the coexistent hypertension plays a predominant role in the progression of chronic kidney diseases (CKD). The role of renal perfusion pressure (RPP) in the progression of CKD is supported by the absence of glomerular injury in a normotensive rat remnant kidney model and that there is strong evidence against the blood pressure-independent renoprotection by angiotensin inhibition. Thus, RPP-induced damage plays a central role in the progression of CKD.  However, it remains unclear how increased RPP produces kidney damage. In particular, despite the findings that impaired renal autoregulation transmits the elevated RPP into the renal microvasculature, causing RPP-induced renal injury, little is known regarding the molecular mechanism mediating pressure-induced renal injury. This topic may need to be highlighted in next meeting.


  • Hypertension and the Progression of Chronic Kidney Disease
    Karen Griffin — Medicine, Loyola University Medical Center

  • Novel Signaling in Renal Autoregulation
    Zhengrong Guan — Medicine, University of Alabama at Birmingham

  • The Role of Renal Perfusion Pressure in Renal Immune Cell Infiltration
    Louise Evans — Integrative Biology and Physiology, University of Minnesota

  • Molecular Signals Mediating Hypertension-Induced Renal Injury
    Ningjun Li — Dept. of Pharmacology & Toxicology, Virginia Commonwealth University

  • Co-chair
    Minolfa Prieto —

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