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Crosstalk between Metabolic Disorders and Mitochondrial Oxidative Stress

Symposium — Monday, April 8, 2019 — 1:30 PM - 3:00 PM — Convention Center, Room W311C
Endocrinology and Metabolism Section — Chair: Sergey I. Dikalov — Co-Chair: Michael N. Sack
Cosponsored by Physiological Reviews

It is known that metabolic disorders increase risk of hypertension and cardiovascular disease. On the other hand, hypertension is frequently associated with several metabolic abnormalities such as obesity, glucose intolerance, and dyslipidemia. These pathological conditions are associated with altered mitochondrial function and oxidative stress suggesting the crosstalk between metabolic disorders and mitochondrial oxidative stress. Our recent research has uncovered a novel cross-talk between mitochondrial hyperacetylation and mitochondrial oxidative stress. Metabolic disorders such as hyperglycemia and hyperlipidemia cause mitochondrial hyperacetylation which leads to mitochondrial dysfunction and overproduction of mitochondrial ROS. On the other hand, mitochondrial oxidative stress in hypoxia and inflammation alter mitochondrial metabolism which contributes to development of pathological conditions. This creates a vicious cycle of “Metabolic Disorders and Mitochondrial Oxidative Stress” which represents the basic principle and is applicable to multiple disease states. This crosstalk identifies a novel targets for treatment of metabolic disorders and treatment of cardiovascular diseases. In this multidisciplinary symposium we will discuss novel physiological and pathological aspects of mitochondrial acetylation, metabolic regulations, production of mitochondrial reactive oxygen species in metabolic regulations, vascular dysfunction and pulmonary arterial hypertension. Our speakers are world-known experts in the field. They will demonstrate the molecular mechanisms of crosstalk between metabolic disorders and mitochondrial oxidative stress, and show the translational potential in multiple pathological conditions associated with metabolic disorders, vascular dysfunction and hypertension.

Speakers

  • Mitochondrial Deacetylase Sirt3 in the Crosstalk Between Vascular Oxidative Stress and Mitochondrial Dysfunction in Hypertension
    Sergey I. Dikalov — Medicine, Vanderbilt University Medical Center

  • Modulation of Redox Cell Signaling and Metabolism by GCN5L1 Mediated Lysine Acetylation in Gluconeogenesis
    Michael N. Sack — NIH/NHLBI

  • Redox Biology and Metabolism in Pulmonary Arterial Hypertension
    James D. West — Medicine, Vanderbilt University Medical Center





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