2019 About APS EB 2019 Information

Autonomic Control of Metabolism

Symposium — Sunday, April 7, 2019 — 3:30 PM - 5:00 PM — Convention Center, Room W311B
Neural Control and Autonomic Regulation Section — Chair: Virginie M. Aubert — Co-Chair: Mohamad Mokadem

The autonomic nervous system, with its two branches the parasympathetic and the sympathetic, plays a pivotal role in the regulation of many physiological responses to maintain metabolic homeostasis in variable target tissues. In general, afferent or sensory fibers transmit metabolic information to the central nervous system, while efferent or motor fibers provide the major neural pathway from the brain to peripheral tissues. An imbalance between the two branches or the two arms of the autonomic nervous system branches is observed in many pathologic conditions. However, new developing technologies in selective electrostimulation, pharmacogenetics and advanced surgical techniques may allow careful manipulation of neuronal tracts of interest for possible future therapeutic purpose. The activation or inhibition of tissue-specific neural fibers can have a significant effect on key metabolic processes such as hepatic or skeletal muscle glucose trafficking, adipose tissue lipolysis - therefore weight loss- and even regulation of immune cell activity. Even though many techniques in neuroscience and molecular genetics are currently available to study the function of the autonomic nervous system, many aspects are still unknown regarding the extent of regulation of the parasympathetic and sympathetic nervous systems to glucose, energy, and immune homeostasis.

This symposium is intended to highpoint new knowledge gained in recent years about the extent of autonomic regulation of glucose, energy, and immune-metabolism. The speakers will discuss the fundamental discoveries regarding the autonomic regulation of glucose and energy homeostasis in the setting of a well-proven therapy to manage obesity and diabetes. In addition, a novel concept will be discussed introducing possible manipulating of the vagus nerve for immuno-modulation of metabolism by means of pharmacogenetics.


  • Gut’s Sympathetic Nerve Regulate Energy and Metabolism after Gastric Bypass
    Mohamad Mokadem — Internal Medicine, University of Iowa

  • The Role of the Gut-Brain Axis in Regulating Glucose Homeostasis
    Darleen Sandoval — Surgery, University of Michigan

  • A Sympathetic View of Fatty Liver
    Colin Young — The George Washington University, Pharmacology and Physiology

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